Scutellaria baicalensis Extracts and Flavonoids Protect Rat L6 Cells from Antimycin A-Induced Mitochondrial Dysfunction
Joint Authors
Im, A-Rang
Kim, Young-Hwa
Uddin, Md. Romij
Lee, Hye Won
Kim, Yun Hee
Jung, Woo Suk
Kang, Bong Ju
Mun, Chun Sun
Chae, Sungwook
Lee, Mi-Young
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Antimycin A (AMA) damages mitochondria by inhibiting mitochondrial electron transport and can produce reactive oxygen species (ROS).
ROS formation, aging, and reduction of mitochondrial biogenesis contribute to mitochondrial dysfunction.
The present study sought to investigate extracts of Scutellaria baicalensis and its flavonoids (baicalin, baicalein, and wogonin), whether they could protect mitochondria against oxidative damage.
The viability of L6 cells treated with AMA increased in the presence of flavonoids and extracts of S.
baicalensis.
ATP production decreased in the AMA treated group, but increased by 50% in cells treated with flavonoids (except wogonin) and extracts of S.
baicalensis compared to AMA-treated group.
AMA treatment caused a significant reduction (depolarized) in mitochondrial membrane potential (MMP), whereas flavonoid treatment induced a significant increase in MMP.
Mitochondrial superoxide levels increased in AMA treated cells, whereas its levels decreased when cells were treated with flavonoids or extracts of S.
baicalensis.
L6 cells treated with flavonoids and extracts of S.
baicalensis increased their levels of protein expression compared with AMA-treated cells, especially water extracts performed the highest levels of protein expression.
These results suggest that the S.
baicalensis extracts and flavonoids protect against AMA-induced mitochondrial dysfunction by increasing ATP production, upregulating MMP, and enhancing mitochondrial function.
American Psychological Association (APA)
Im, A-Rang& Kim, Young-Hwa& Uddin, Md. Romij& Lee, Hye Won& Chae, Sungwook& Kim, Yun Hee…[et al.]. 2012. Scutellaria baicalensis Extracts and Flavonoids Protect Rat L6 Cells from Antimycin A-Induced Mitochondrial Dysfunction. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028377
Modern Language Association (MLA)
Im, A-Rang…[et al.]. Scutellaria baicalensis Extracts and Flavonoids Protect Rat L6 Cells from Antimycin A-Induced Mitochondrial Dysfunction. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028377
American Medical Association (AMA)
Im, A-Rang& Kim, Young-Hwa& Uddin, Md. Romij& Lee, Hye Won& Chae, Sungwook& Kim, Yun Hee…[et al.]. Scutellaria baicalensis Extracts and Flavonoids Protect Rat L6 Cells from Antimycin A-Induced Mitochondrial Dysfunction. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028377