A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease
Joint Authors
Wang, Xia
Xu, Xue
Tao, Weiyang
Li, Yan
Yang, Ling
Wang, Yonghua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-29
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
Clinical trials reveal that multiherb prescriptions of herbal medicine often exhibit pharmacological and therapeutic superiority in comparison to isolated single constituents.
However, the synergistic mechanisms underlying this remain elusive.
To address this question, a novel systems biology model integrating oral bioavailability and drug-likeness screening, target identification, and network pharmacology method has been constructed and applied to four clinically widely used herbs Radix Astragali Mongolici, Radix Puerariae Lobatae, Radix Ophiopogonis Japonici, and Radix Salviae Miltiorrhiza which exert synergistic effects of combined treatment of cardiovascular disease (CVD).
Results.
The results show that the structural properties of molecules in four herbs have substantial differences, and each herb can interact with significant target proteins related to CVD.
Moreover, the bioactive ingredients from different herbs potentially act on the same molecular target (multiple-drug-one-target) and/or the functionally diverse targets but with potentially clinically relevant associations (multiple-drug-multiple-target-one-disease).
From a molecular/systematic level, this explains why the herbs within a concoction could mutually enhance pharmacological synergy on a disease.
Conclusions.
The present work provides a new strategy not only for the understanding of pharmacological synergy in herbal medicine, but also for the rational discovery of potent drug/herb combinations that are individually subtherapeutic.
American Psychological Association (APA)
Wang, Xia& Xu, Xue& Tao, Weiyang& Li, Yan& Wang, Yonghua& Yang, Ling. 2012. A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1028378
Modern Language Association (MLA)
Wang, Xia…[et al.]. A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-1028378
American Medical Association (AMA)
Wang, Xia& Xu, Xue& Tao, Weiyang& Li, Yan& Wang, Yonghua& Yang, Ling. A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1028378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028378