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Chinese Herbal Medicine Paratherapy for Parkinson's Disease: A Meta-Analysis of 19 Randomized Controlled Trials
Joint Authors
Fu, Deng-lei
Xie, Cheng-long
Wang, Yan
Zheng, Guo-qing
Lu, Lin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-13
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Parkinson's disease (PD) is a common and debilitating neurodegenerative disorder that needs long-term levodopa administration and can result in progressive deterioration of body functions, daily activities and participation.
The objective of this meta-analysis evaluates the clinical efficacy and safety of Chinese herbal medicine (CHM) as an adjunct therapy for PD patients.
Methodological issues include a systematic literature search between 1950 and April 2011 to identify randomized trials involving CHM adjuvant therapy versus western conventional treatment.
The outcome measures assessed were the reduction in scores of Unified Parkinson's Disease Rating Scale (UPDRS) and adverse effects.
19 trials involving 1371 participants were included in the meta-analysis.
As compared to western conventional treatment, CHM adjuvant therapy resulted in greater improvement in UPDRS I, II, III, IV scores, and UPDRS I–IV total scores (P<0.001).
Adverse effects were reported in 9 studies.
The side effects in CHM adjuvant therapy group were generally less than or lighter than the conventional treatment group.
In conclusion, CHM adjuvant therapy may potentially alleviate symptoms of PD and generally appeared to be safe and well tolerated by PD patients.
However, well-designed, randomized, placebo-controlled clinical trials are still needed due to the generally low methodological quality of the included studies.
American Psychological Association (APA)
Wang, Yan& Xie, Cheng-long& Lu, Lin& Fu, Deng-lei& Zheng, Guo-qing. 2012. Chinese Herbal Medicine Paratherapy for Parkinson's Disease: A Meta-Analysis of 19 Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1028385
Modern Language Association (MLA)
Wang, Yan…[et al.]. Chinese Herbal Medicine Paratherapy for Parkinson's Disease: A Meta-Analysis of 19 Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-1028385
American Medical Association (AMA)
Wang, Yan& Xie, Cheng-long& Lu, Lin& Fu, Deng-lei& Zheng, Guo-qing. Chinese Herbal Medicine Paratherapy for Parkinson's Disease: A Meta-Analysis of 19 Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1028385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028385