Rokumi-jio-gan-Containing Prescriptions Attenuate Oxidative Stress, Inflammation, and Apoptosis in the Remnant Kidney
Joint Authors
Yokozawa, Takako
Okamoto, Takuya
Tanaka, Takashi
Lee, Sul Lim
Park, Chan Hum
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-29
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Two Rokumi-jio-gan-containing prescriptions (Hachimi-jio-gan and Bakumi-jio-gan) were selected to examine their actions in nephrectomized rats.
Each prescription was given orally to rats for 10 weeks after the excision of five-sixths of their kidney volumes, and its effect was compared with non-nephrectomized and normal rats.
Rats given Hachimi-jio-gan and Bakumi-jio-gan showed an improvement of renal functional parameters such as serum urea nitrogen, creatinine, creatinine clearance, and urinary protein.
The nephrectomized rats exhibited the up-regulation of nicotinamide adenine dinucleotide phosphate oxidase subunits, c-Jun N-terminal kinase (JNK), phosphor-JNK, c-Jun, transforming growth factor-β1, nuclear factor-kappa B, cyclooxygenase-2, inducible nitric oxide synthase, monocyte chemotactic protein-1, intracellular adhesion molecule-1, Bax, cytochrome c, and caspase-3, and down-regulation of NF-E2-related factor 2, heme oxygenase-1, and survivin; however, Bakumi-jio-gan administration acts as a regulator in inflammatory reactions caused by oxidative stress in renal failure.
Moreover, the JNK pathway and apoptosis-related protein expressions, Bax, caspase-3, and survivin, were ameliorated to the normal levels by Hachimi-jio-gan administration.
The development of renal lesions, glomerular sclerosis, tubulointerstitial damage, and arteriolar sclerotic lesions, estimated by histopathological evaluation and scoring, was strong in the groups administered Hachimi-jio-gan rather than Bakumi-jio-gan.
This study suggests that Rokumi-jio-gan-containing prescriptions play a protective role in the progression of renal failure.
American Psychological Association (APA)
Park, Chan Hum& Lee, Sul Lim& Okamoto, Takuya& Tanaka, Takashi& Yokozawa, Takako. 2012. Rokumi-jio-gan-Containing Prescriptions Attenuate Oxidative Stress, Inflammation, and Apoptosis in the Remnant Kidney. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1028404
Modern Language Association (MLA)
Park, Chan Hum…[et al.]. Rokumi-jio-gan-Containing Prescriptions Attenuate Oxidative Stress, Inflammation, and Apoptosis in the Remnant Kidney. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-1028404
American Medical Association (AMA)
Park, Chan Hum& Lee, Sul Lim& Okamoto, Takuya& Tanaka, Takashi& Yokozawa, Takako. Rokumi-jio-gan-Containing Prescriptions Attenuate Oxidative Stress, Inflammation, and Apoptosis in the Remnant Kidney. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1028404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028404