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Modified Huo-Luo-Xiao-Ling Dan Suppresses Adjuvant Arthritis by Inhibiting Chemokines and Matrix-Degrading Enzymes
Joint Authors
Lee, David Y.-W.
Ma, Zhongze
Moudgil, Kamal D.
Berman, Brian
Nanjundaiah, Siddaraju M.
Lao, Lixing
Fong, Harry H. S.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Rheumatoid arthritis (RA) is a chronic inflammatory disease affecting the joints that can lead to deformities and disability.
The prolonged use of conventionally used drugs is associated with severe adverse reactions.
Therefore, safer and less expensive therapeutic products are continually being sought.
Huo-Luo-Xiao-Ling dan (HLXL), a traditional Chinese herbal mixture, and its modified versions possess anti-arthritic activity.
In this paper, we examined the influence of modified HLXL on two of the key mediators of arthritic inflammation and tissue damage, namely, chemokines and matrix-metalloproteinases (MMPs) in the rat adjuvant-induced arthritis (AA) model of RA.
We treated arthritic Lewis rats with HLXL (2.3 g/kg) by daily gavage beginning at the onset of AA.
The control rats received the vehicle.
At the peak phase of AA, rats were sacrificed and their draining lymph node cells (LNC) and spleen adherent cells (SAC) were tested.
The HLXL-treated rats showed a significant reduction in the levels of chemokines (RANTES, MCP-1, MIP-1α, and GRO/KC), MMPs (MMP 2 and 9), as well as cytokines (IL-6 and IL-17) that induce them, compared to the control vehicle-treated rats.
Thus, HLXL controls arthritis in part by suppressing the mediators of immune pathology, and it might offer a promising alternative/adjunct treatment for RA.
American Psychological Association (APA)
Nanjundaiah, Siddaraju M.& Lee, David Y.-W.& Ma, Zhongze& Fong, Harry H. S.& Lao, Lixing& Berman, Brian…[et al.]. 2012. Modified Huo-Luo-Xiao-Ling Dan Suppresses Adjuvant Arthritis by Inhibiting Chemokines and Matrix-Degrading Enzymes. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028405
Modern Language Association (MLA)
Nanjundaiah, Siddaraju M.…[et al.]. Modified Huo-Luo-Xiao-Ling Dan Suppresses Adjuvant Arthritis by Inhibiting Chemokines and Matrix-Degrading Enzymes. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028405
American Medical Association (AMA)
Nanjundaiah, Siddaraju M.& Lee, David Y.-W.& Ma, Zhongze& Fong, Harry H. S.& Lao, Lixing& Berman, Brian…[et al.]. Modified Huo-Luo-Xiao-Ling Dan Suppresses Adjuvant Arthritis by Inhibiting Chemokines and Matrix-Degrading Enzymes. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028405