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Early Blockade of TLRs MyD88-Dependent Pathway May Reduce Secondary Spinal Cord Injury in the Rats
Joint Authors
Kuang, Fang
Yao, An-hui
Ma, Quan-rui
Cheng, Peng
Liu, Ling
Jia, Li-Yun
Ju, Gong
Zhang, Yu-Kai
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-22
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
To determine the role of toll-like receptors (TLRs) myeloid differentiation factor 88 (MyD88) dependent pathway in the spinal cord secondary injury, compression injury was made at T8 segment of the spinal cord in adult male Sprague-Dawley rats.
Shown by RT-PCR, TLR4 mRNA in the spinal cord was quickly elevated after compression injury.
Intramedullary injection of MyD88 inhibitory peptide (MIP) resulted in significant improvement in locomotor function recovery at various time points after surgery.
Meanwhile, injury area, p38 phosphorylation, and proinflammation cytokines in the injured spinal cord were significantly reduced in MIP-treated animals, compared with control peptide (CP) group.
These data suggest that TLRs MyD88-dependent pathway may play an important role in the development of secondary spinal cord injury, and inhibition of this pathway at early time after primary injury could effectively protect cells from inflammation and apoptosis and therefore improve the functional recovery.
American Psychological Association (APA)
Yao, An-hui& Jia, Li-Yun& Zhang, Yu-Kai& Ma, Quan-rui& Cheng, Peng& Liu, Ling…[et al.]. 2012. Early Blockade of TLRs MyD88-Dependent Pathway May Reduce Secondary Spinal Cord Injury in the Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1028408
Modern Language Association (MLA)
Yao, An-hui…[et al.]. Early Blockade of TLRs MyD88-Dependent Pathway May Reduce Secondary Spinal Cord Injury in the Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-1028408
American Medical Association (AMA)
Yao, An-hui& Jia, Li-Yun& Zhang, Yu-Kai& Ma, Quan-rui& Cheng, Peng& Liu, Ling…[et al.]. Early Blockade of TLRs MyD88-Dependent Pathway May Reduce Secondary Spinal Cord Injury in the Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1028408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028408