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Antiprotozoal and Antimycobacterial Activities of Pure Compounds from Aristolochia elegans Rhizomes
Joint Authors
Jiménez-Arellanes, Adelina
León-Díaz, Rosalba
Meckes, Mariana
Tapia, Amparo
Luna-Herrera, Julieta
Yépez-Mulia, Lilián
Molina-Salinas, Gloria María
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We analyzed the antimycobacterial activity of the hexane extract of rhizomes from Aristolochia elegans.
Some compounds of this extract were purified and tested against a group of drug-resistant Mycobacterium tuberculosis strains.
We also evaluated their antiprotozoal activities.
The hexane extract was active against M.
tuberculosis H37Rv at a MIC=100 μg mL−1; the pure compounds eupomatenoid-1, fargesin, and (8R,8′R,9R)-cubebin were active against M.
tuberculosis H37Rv (MIC = 50 μg mL−1), while fargesin presented activity against three monoresistant strains of M.
tuberculosis H37Rv and a MDR clinical isolate of M.
tuberculosis (MIC<50 μg mL−1).
Both the extract and eupomatenoid-1 were very active against E.
histolytica and G.
lamblia (IC50<0.624 μg mL−1); in contrast, fargesin and (8R,8′R,9R)-cubebin were moderately active (IC50<275 μg mL−1).
In this context, two compounds responsible for the antimycobacterial presented by A.
elegans are fargesin and cubebin, although others may exert this activity also.
In addition to the antimycobacterial activity, the hexane extract has important activity against E.
histolytica and G.
lamblia, and eupomatenoid-1 is one of the compounds responsible for the antiparasite activity.
American Psychological Association (APA)
Jiménez-Arellanes, Adelina& León-Díaz, Rosalba& Meckes, Mariana& Tapia, Amparo& Molina-Salinas, Gloria María& Luna-Herrera, Julieta…[et al.]. 2012. Antiprotozoal and Antimycobacterial Activities of Pure Compounds from Aristolochia elegans Rhizomes. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028412
Modern Language Association (MLA)
Jiménez-Arellanes, Adelina…[et al.]. Antiprotozoal and Antimycobacterial Activities of Pure Compounds from Aristolochia elegans Rhizomes. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028412
American Medical Association (AMA)
Jiménez-Arellanes, Adelina& León-Díaz, Rosalba& Meckes, Mariana& Tapia, Amparo& Molina-Salinas, Gloria María& Luna-Herrera, Julieta…[et al.]. Antiprotozoal and Antimycobacterial Activities of Pure Compounds from Aristolochia elegans Rhizomes. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028412