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Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity
Joint Authors
Burdan, Franciszek
Matysiak, Wlodzimierz
Gieroba, Renata
Korobowicz, Elzbieta
Murias, Marek
Dudka, Jaroslaw
Korga, Agnieszka
Mandziuk, Slawomir
Jodlowska-Jedrych, Barbara
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of the study was to evaluate the effect of resveratrol in doxorubicin-induced cardiac and hepatic toxicity.
Doxorubicin was administered once a week throughout the period of 7 weeks with 1.0 or 2.0 mg/kg body weight or concomitantly with resveratrol (20 mg/kg of feed).
Heart and liver toxicity was histologically and biochemically evaluated.
Resveratrol protected from the heart lipid peroxidation caused by 1 mg doxorubicin and it sharply diminished superoxide dismutase activity.
An insignificant effect of resveratrol on the lipid peroxidation level and the superoxide dismutase activity was observed in the hearts of rats administered a higher dose of doxorubicin.
However, resveratrol attenuate necrosis and other cardiac histopathological changes were induced by a high dose of doxorubicin.
Interestingly, it slightly intensified adverse cardiac histological changes in rats receiving a lower dose of doxorubicin.
Resveratrol did not have any protective effect on the hepatic oxidative stress, while exerting a mild beneficial effect on the morphological changes caused by doxorubicin.
All in all, this study has shown different effects of resveratrol on dose-related doxorubicin-induced heart and liver toxicity.
Resveratrol may modulate the hepatic and cardiac effect of doxorubicin, depending on the drug dose.
American Psychological Association (APA)
Dudka, Jaroslaw& Gieroba, Renata& Korga, Agnieszka& Burdan, Franciszek& Matysiak, Wlodzimierz& Jodlowska-Jedrych, Barbara…[et al.]. 2012. Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028421
Modern Language Association (MLA)
Dudka, Jaroslaw…[et al.]. Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028421
American Medical Association (AMA)
Dudka, Jaroslaw& Gieroba, Renata& Korga, Agnieszka& Burdan, Franciszek& Matysiak, Wlodzimierz& Jodlowska-Jedrych, Barbara…[et al.]. Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028421