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Effects of 12-Week Bacopa monnieri Consumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers
Joint Authors
Wattanathorn, Jintanaporn
Peth-Nui, Tatimah
Piyavhatkul, Nawanant
Rangseekajee, Poonsri
Vittaya-areekul, Sakchai
Tong-Un, Terdthai
Muchimapura, Supaporn
Ingkaninan, Kornkanok
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
At present, the scientific evidence concerning the effect of Bacopa monnieri on brain activity together with working memory is less available.
Therefore, we aimed to determine the effect of B.
monnieri on attention, cognitive processing, working memory, and cholinergic and monoaminergic functions in healthy elderly.
A randomized double-blind placebo-controlled design was utilized.
Sixty healthy elderly subjects (mean age 62.62 years; SD 6.46), consisting of 23 males and 37 females, received either a standardized extract of B.
monnieri (300 and 600 mg) or placebo once daily for 12 weeks.
The cholinergic and monoaminergic systems functions were determined using AChE and MAO activities.
Working memory was assessed using percent accuracy and reaction time of various memory tests as indices, whereas attention and cognitive processing were assessed using latencies and amplitude of N100 and P300 components of event-related potential.
All assessments were performed before treatment, every four weeks throughout study period, and at four weeks after the cessation of intervention.
B.
monnieri-treated group showed improved working memory together with a decrease in both N100 and P300 latencies.
The suppression of plasma AChE activity was also observed.
These results suggest that B.
monnieri can improve attention, cognitive processing, and working memory partly via the suppression of AChE activity.
American Psychological Association (APA)
Peth-Nui, Tatimah& Wattanathorn, Jintanaporn& Muchimapura, Supaporn& Tong-Un, Terdthai& Piyavhatkul, Nawanant& Rangseekajee, Poonsri…[et al.]. 2012. Effects of 12-Week Bacopa monnieri Consumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028422
Modern Language Association (MLA)
Peth-Nui, Tatimah…[et al.]. Effects of 12-Week Bacopa monnieri Consumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028422
American Medical Association (AMA)
Peth-Nui, Tatimah& Wattanathorn, Jintanaporn& Muchimapura, Supaporn& Tong-Un, Terdthai& Piyavhatkul, Nawanant& Rangseekajee, Poonsri…[et al.]. Effects of 12-Week Bacopa monnieri Consumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028422
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028422