Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder
Joint Authors
Zhang, Li-Ming
Yao, Jia-Zhi
Li, Yang
Li, Kai
Chen, Hong-Xia
Li, Yun-Feng
Zhang, You-Zhi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The dysregulation of the serotonergic system has long been recognized as an important factor underlying the pathophysiology of PTSD.
To date, SSRIs have already been established as the firstline pharmacotherapeutic agents for treating acute and chronic PTSD.
However, SSRIs largely have several disadvantages which limit their utility.
Our previous study has also shown that administration of the total flavonoids, isolated from the extract of Xiaobuxin-Tang (XBXT, mild mind-easing decoction), comprising four Chinese medicines including Haematitum, Flos Inulae, Folium Phyllostachydis Henonis, and Semen Sojae Preparatum, exerted significant antidepressant-like effect in chronically mildly stressed rats, possibly mediated by serotonergic activation.
Since the central serotonergic dysfunction is an important and well-known cause mediating the pathophysiology of trauma-related symptoms in PTSD, it is reasonable to predict that flavonoids may exert therapeutic effects on PTSD in animal models.
Therefore, the present study aims to examine the effect of flavonoids in alleviating the enhanced anxiety and fear response induced in two PTSD animal models.
Ser, an SSRI, was administered as a positive control.
Furthermore, the changes of brain monoaminergic neurotransmitters after chronic flavonoids administration have also been assessed in SPS-treated rats.
American Psychological Association (APA)
Zhang, Li-Ming& Yao, Jia-Zhi& Li, Yang& Li, Kai& Chen, Hong-Xia& Zhang, You-Zhi…[et al.]. 2012. Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028432
Modern Language Association (MLA)
Zhang, Li-Ming…[et al.]. Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028432
American Medical Association (AMA)
Zhang, Li-Ming& Yao, Jia-Zhi& Li, Yang& Li, Kai& Chen, Hong-Xia& Zhang, You-Zhi…[et al.]. Anxiolytic Effects of Flavonoids in Animal Models of Posttraumatic Stress Disorder. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028432