Protective Effect of Proanthocyanidin against Diabetic Oxidative Stress
Joint Authors
Yokozawa, Takako
Cho, Eun Ju
Kim, Ji Hyun
Park, Chan Hum
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We investigated the antidiabetic potential of proanthocyanidin and its oligomeric form in STZ-induced diabetic model rats and db/db type 2 diabetic mice.
Proanthocyanidin ameliorated the diabetic condition by significant decreases of serum glucose, glycosylated protein, and serum urea nitrogen as well as decreases of urinary protein and renal-AGE in STZ-induced diabetic rats and decrease of serum glucose as well as significant decrease of glycosylated protein in db/db type 2 diabetic mice.
The suppression of ROS generation and elevation of the GSH/GSSG ratio were also observed in the groups administered proanthocyanidin.
Moreover, proanthocyanidin, especially its oligomeric form, affected the inflammatory process with the regulation of related protein expression, iNOS, COX-2 and upstream regulators, NF-κB, and the IκB-α.
In addition, it had a marked effect on hyperlipidemia through lowering significant levels of triglycerides, total cholesterol, and NEFA.
Moreover, expressions in the liver of SREBP-1 and SREBP-2 were downregulated by the administration of proanthocyanidins.
The protective effect against hyperglycemia and hyperlipidemia in type 1 and 2 diabetic models was significantly strong in the groups administered the oligomeric rather than polymeric form.
This suggests that oligomers act as a regulator in inflammatory reactions caused by oxidative stress in diabetes.
American Psychological Association (APA)
Yokozawa, Takako& Cho, Eun Ju& Park, Chan Hum& Kim, Ji Hyun. 2011. Protective Effect of Proanthocyanidin against Diabetic Oxidative Stress. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028433
Modern Language Association (MLA)
Yokozawa, Takako…[et al.]. Protective Effect of Proanthocyanidin against Diabetic Oxidative Stress. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028433
American Medical Association (AMA)
Yokozawa, Takako& Cho, Eun Ju& Park, Chan Hum& Kim, Ji Hyun. Protective Effect of Proanthocyanidin against Diabetic Oxidative Stress. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028433
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028433