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Effect of Piper sarmentosum Extract on the Cardiovascular System of Diabetic Sprague-Dawley Rats: Electron Microscopic Study
Joint Authors
Zar Chi, Thent
Lin, Teoh Seong
Zakaria, Zaiton
Das, Srijit
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Although Piper sarmentosum (PS) is known to possess the antidiabetic properties, its efficacy towards diabetic cardiovascular tissues is still obscured.
The present study aimed to observe the electron microscopic changes on the cardiac tissue and proximal aorta of experimental rats treated with PS extract.
Thirty-two male Sprague-Dawley rats were divided into four groups: untreated control group (C), PS-treated control group (CTx), untreated diabetic group (D), and PS-treated diabetic group (DTx).
Intramuscular injection of streptozotocin (STZ, 50 mg/kg body weight) was given to induce diabetes.
Following 28 days of diabetes induction, PS extract (0.125 g/kg body weight) was administered orally for 28 days.
Body weight, fasting blood glucose, and urine glucose levels were measured at 4-week interval.
At the end of the study, cardiac tissues and the aorta were viewed under transmission electron microscope (TEM).
DTx group showed increase in body weight and decrease in fasting blood glucose and urine glucose level compared to the D group.
Under TEM study, DTx group showed lesser ultrastructural degenerative changes in the cardiac tissues and the proximal aorta compared to the D group.
The results indicate that PS restores ultrastructural integrity in the diabetic cardiovascular tissues.
American Psychological Association (APA)
Zar Chi, Thent& Lin, Teoh Seong& Das, Srijit& Zakaria, Zaiton. 2012. Effect of Piper sarmentosum Extract on the Cardiovascular System of Diabetic Sprague-Dawley Rats: Electron Microscopic Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028438
Modern Language Association (MLA)
Zar Chi, Thent…[et al.]. Effect of Piper sarmentosum Extract on the Cardiovascular System of Diabetic Sprague-Dawley Rats: Electron Microscopic Study. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028438
American Medical Association (AMA)
Zar Chi, Thent& Lin, Teoh Seong& Das, Srijit& Zakaria, Zaiton. Effect of Piper sarmentosum Extract on the Cardiovascular System of Diabetic Sprague-Dawley Rats: Electron Microscopic Study. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028438
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028438