Clinical Efficacy and Safety of Buyang Huanwu Decoction for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of 19 Randomized Controlled Trials
Joint Authors
Hao, Chi-zi
Wu, Fan
Shen, Jiangang
Liao, Wei-jing
Fu, Deng-lei
Zheng, Guo-qing
Lu, Lin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Buyang Huanwu Decoction (BHD) is a well-known traditional Chinese herbal prescription for treating stroke-induced disability.
The objective of this study was to evaluate the efficacy and safety of BHD for acute ischemic stroke.
A systematic literature search was performed in 6 databases until February 2012.
Randomized controlled clinical trials (RCTs) that evaluate efficacy and safety of BHD for acute ischemic stroke were included.
Nineteen RCTs with 1580 individuals were identified.
The studies were generally of low methodological quality.
Only one of the trial included death or dependency as a primary outcome measure.
Only 4 trials reported adverse events.
Meta-analysis showed the clinical effective rate of neurological deficit improvement favoring BHD when compared with western conventional medicines (WCM), P<0.001.
There is significant difference in the neurologic deficit score between the BHD treatment group and the WCM control group, P<0.001.
In Conclusion, BHD appears to improve neurological deficit and seems generally safe in patients with acute ischemic stroke.
However, the current evidence is insufficient to support a routine use of BHD for acute ischemic stroke due to the poor methodological quality and lack of adequate safety data of the included studies.
Further rigorously designed trials are required.
American Psychological Association (APA)
Hao, Chi-zi& Wu, Fan& Shen, Jiangang& Lu, Lin& Fu, Deng-lei& Liao, Wei-jing…[et al.]. 2012. Clinical Efficacy and Safety of Buyang Huanwu Decoction for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of 19 Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028439
Modern Language Association (MLA)
Hao, Chi-zi…[et al.]. Clinical Efficacy and Safety of Buyang Huanwu Decoction for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of 19 Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028439
American Medical Association (AMA)
Hao, Chi-zi& Wu, Fan& Shen, Jiangang& Lu, Lin& Fu, Deng-lei& Liao, Wei-jing…[et al.]. Clinical Efficacy and Safety of Buyang Huanwu Decoction for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of 19 Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028439
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028439