![](/images/graphics-bg.png)
Electroacupuncture Attenuates Ovalbumin-Induced Allergic Asthma via Modulating CD4+CD25+ Regulatory T Cells
Joint Authors
Lee, Gihyun
Kwon, Youngjoo
Sohn, Sung-Hwa
Kim, Youngeun
Lee, Hyejung
Bae, Hyunsu
Shin, Minkyu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A mouse pulmonary hypersensitivity experimental model that mimics human asthma was developed, and electroacupuncture (EA) treatment was shown to reduce allergic inflammatory processes.
In addition, we also assessed whether the beneficial effects of EA on allergic asthma could be correlated with CD4+CD25+Foxp3+ regulatory T cells (Treg).
Cellular profiles and histopathologic analysis demonstrated that peribronchial and perivascular inflammatory cell infiltrates were significantly decreased in the EA-treated groups when compared to the OVA and anti-CD25 Ab-injected (Treg depletion) groups.
Furthermore, total BAL cells were reduced in the EA groups when compared to other groups.
Interestingly, the population of CD4+CD25+Foxp3+Tregs in pneumonocytes increased in EA-treated group when compared to OVA and Treg depletion groups.
These results imply that EA stimulation at ST 36 may affect CD4+CD25+Foxp3+ Treg in an OVA-induced experimental model and may enhance Treg function by suppressing other T cells and limiting the immune response.
American Psychological Association (APA)
Kwon, Youngjoo& Sohn, Sung-Hwa& Lee, Gihyun& Kim, Youngeun& Lee, Hyejung& Shin, Minkyu…[et al.]. 2012. Electroacupuncture Attenuates Ovalbumin-Induced Allergic Asthma via Modulating CD4+CD25+ Regulatory T Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028452
Modern Language Association (MLA)
Kwon, Youngjoo…[et al.]. Electroacupuncture Attenuates Ovalbumin-Induced Allergic Asthma via Modulating CD4+CD25+ Regulatory T Cells. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028452
American Medical Association (AMA)
Kwon, Youngjoo& Sohn, Sung-Hwa& Lee, Gihyun& Kim, Youngeun& Lee, Hyejung& Shin, Minkyu…[et al.]. Electroacupuncture Attenuates Ovalbumin-Induced Allergic Asthma via Modulating CD4+CD25+ Regulatory T Cells. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028452
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028452