Effects of Thymol and Carvacrol, Constituents of Thymus vulgaris L. Essential Oil, on the Inflammatory Response
Joint Authors
Grespan, Renata
Estevão-Silva, Camila Fernanda
Kummer, Raquel
Cuman, Roberto Kenji Nakamura
Cunha, Joice Maria
Fachini-Queiroz, Fernanda Carolina
Carvalho, Maria Dalva de Barros
Bersani-Amado, Ciomar Aparecida
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Thyme (Thymus vulgaris L., Lamiaceae) is an aromatic and medicinal plant that has been used in folk medicine, phytopharmaceutical preparations, food preservatives, and as an aromatic ingredient.
The effect of Thymus vulgaris essential oil (TEO) and its isolated constituents thymol and cavacrol (CVL) were studied in the following experimental models: ear edema, carrageenan-induced pleurisy, and chemotaxis in vitro.
In the pleurisy model, TEO, CVL, and thymol significantly inhibited inflammatory edema.
However, only TEO and CVL inhibited leukocyte migration.
In the in vitro chemotaxis experiment, CVL inhibited leukocyte migration, whereas thymol exerted a potent chemoattractant effect.
In the ear edema model, CVL (10 mg/ear), applied topically, reduced edema formation, exerting a topical anti-inflammatory effect.
Thymol did not reduce edema formation but rather presented an irritative response, probably dependent on histamine and prostanoid release.
Our data suggest that the antiinflammatory effects of TEO and CVL are attributable to the inhibition of inflammatory edema and leukocyte migration.
American Psychological Association (APA)
Fachini-Queiroz, Fernanda Carolina& Kummer, Raquel& Estevão-Silva, Camila Fernanda& Carvalho, Maria Dalva de Barros& Cunha, Joice Maria& Grespan, Renata…[et al.]. 2012. Effects of Thymol and Carvacrol, Constituents of Thymus vulgaris L. Essential Oil, on the Inflammatory Response. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028457
Modern Language Association (MLA)
Fachini-Queiroz, Fernanda Carolina…[et al.]. Effects of Thymol and Carvacrol, Constituents of Thymus vulgaris L. Essential Oil, on the Inflammatory Response. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028457
American Medical Association (AMA)
Fachini-Queiroz, Fernanda Carolina& Kummer, Raquel& Estevão-Silva, Camila Fernanda& Carvalho, Maria Dalva de Barros& Cunha, Joice Maria& Grespan, Renata…[et al.]. Effects of Thymol and Carvacrol, Constituents of Thymus vulgaris L. Essential Oil, on the Inflammatory Response. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028457