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Effects of Berberine and Hwangryunhaedok-Tang on Oral Bioavailability and Pharmacokinetics of Ciprofloxacin in Rats
Joint Authors
Ma, Jin Yeul
Hwang, Youn-Hwan
Jang, Doorye
Ha, Jeong-Ho
Jung, Kiyoun
Yun, Hyo-In
Cho, Won-Kyung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Hwangryunhaedok-Tang (HR) and berberine-containing single herbs are used to treat bacterial infection and inflammatory diseases in eastern Asia.
The combination of berberine-containing herbal medicines and ciprofloxacin can be an excellent antibacterial chemotherapy against multidrug resistance bacteria.
To evaluate the pretreatment effect of berberine and HR, vehicle, berberine (25 and 50 mg/kg/day), and HR (1.4 g/kg/day) were daily administered to rats for five consecutive days.
On day 6, ciprofloxacin was administered (10 mg/kg, i.v.
and 20 mg/kg, p.o.) to rats.
To assess cotreatment effect of berberine and ciprofloxacin, berberine (50 mg/kg) and ciprofloxacin (20 mg/kg) were coadministered by single oral gavage.
Pharmacokinetic data were estimated by noncompartmental model.
Compared with ciprofloxacin alone (control group), coadministration of berberine (50 mg/kg) and ciprofloxacin significantly decreased Cmax of ciprofloxacin (P<0.05).
In addition, the pretreatment of berberine (50 mg/kg/day) and HR (1.4 g/kg/day) significantly decreased Cmax and AUC0→∞, compared with control group (P<0.05).
The oral bioavailability of ciprofloxacin was reduced by cotreatment of berberine and pretreatment of berberine and HR.
Our results suggest that the expression of P-glycoprotein and organic anion and/or organic cation transporters (OAT/OCT) could take a role in reduced oral bioavailability of ciprofloxacin by berberine and HR.
American Psychological Association (APA)
Hwang, Youn-Hwan& Cho, Won-Kyung& Jang, Doorye& Ha, Jeong-Ho& Jung, Kiyoun& Yun, Hyo-In…[et al.]. 2012. Effects of Berberine and Hwangryunhaedok-Tang on Oral Bioavailability and Pharmacokinetics of Ciprofloxacin in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028459
Modern Language Association (MLA)
Hwang, Youn-Hwan…[et al.]. Effects of Berberine and Hwangryunhaedok-Tang on Oral Bioavailability and Pharmacokinetics of Ciprofloxacin in Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028459
American Medical Association (AMA)
Hwang, Youn-Hwan& Cho, Won-Kyung& Jang, Doorye& Ha, Jeong-Ho& Jung, Kiyoun& Yun, Hyo-In…[et al.]. Effects of Berberine and Hwangryunhaedok-Tang on Oral Bioavailability and Pharmacokinetics of Ciprofloxacin in Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028459