Citrus ichangensis Peel Extract Exhibits Anti-Metabolic Disorder Effects by the Inhibition of PPARγ and LXR Signaling in High-Fat Diet-Induced C57BL6 Mouse
Joint Authors
Ding, Xiaobo
Gu, Ming
Fan, Shengjie
Lu, Xiong
Zhang, Lu
Liu, Gaigai
Guo, Lu
Jiang, Dong
Zhou, Zhiqin
Huang, Cheng
Zhang, Yu
Li, Yiming
Lu, Yan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Obesity is a common nutritional disorder associated with type 2 diabetes, cardiovascular diseases, dyslipidemia, and certain cancers.
In this study, we investigated the effects of Citrus ichangensis peel extract (CIE) in high-fat (HF) diet-induced obesity mice.
Female C57BL/6 mice were fed a chow diet or an HF diet alone or supplemented with 1% w/w CIE for 8 weeks.
We found that CIE treatment could lower blood glucose level and improve glucose tolerance.
In the HF+CIE group, body weight gain, serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c) levels, and liver triglyceride (TG) and TC concentrations were significantly (P<0.05) decreased relative to those in the HF group.
To elucidate the mechanism of CIE on the metabolism of glucose and lipid, related genes expression in liver were examined.
In liver tissue, CIE significantly decreased the mRNA expression levels of peroxisome proliferator-activated receptor γ (PPARγ) and its target genes, such as fatty acid synthase (FAS) and acyl-CoA oxidase (ACO).
Moreover, CIE also decreased the expression of liver X receptor (LXR) α and β which are involved in lipid and glucose metabolism.
These results suggest that CIE administration could alleviate obesity and related metabolic disorders in HF diet-induced obesity mice through the inhibition of PPARγ and LXR signaling.
American Psychological Association (APA)
Ding, Xiaobo& Fan, Shengjie& Lu, Yan& Zhang, Yu& Gu, Ming& Zhang, Lu…[et al.]. 2012. Citrus ichangensis Peel Extract Exhibits Anti-Metabolic Disorder Effects by the Inhibition of PPARγ and LXR Signaling in High-Fat Diet-Induced C57BL6 Mouse. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028462
Modern Language Association (MLA)
Ding, Xiaobo…[et al.]. Citrus ichangensis Peel Extract Exhibits Anti-Metabolic Disorder Effects by the Inhibition of PPARγ and LXR Signaling in High-Fat Diet-Induced C57BL6 Mouse. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028462
American Medical Association (AMA)
Ding, Xiaobo& Fan, Shengjie& Lu, Yan& Zhang, Yu& Gu, Ming& Zhang, Lu…[et al.]. Citrus ichangensis Peel Extract Exhibits Anti-Metabolic Disorder Effects by the Inhibition of PPARγ and LXR Signaling in High-Fat Diet-Induced C57BL6 Mouse. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028462
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028462