Gallic Acid Attenuates Platelet Activation and Platelet-Leukocyte Aggregation: Involving Pathways of Akt and GSK3β
Joint Authors
Chen, Kuen-Bao
Chang, Shih-Sheng
Lee, Viola S. Y.
Tseng, Yu-Lun
Chang, Kuan-Cheng
Li, Chi-Yuan
Chen, Yuh-Lien
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Platelet activation and its interaction with leukocytes play an important role in atherothrombosis.
Cardiovascular diseases resulted from atherothrombosis remain the major causes of death worldwide.
Gallic acid, a major constituent of red wine and tea, has been believed to have properties of cardiovascular protection, which is likely to be related to its antioxidant effects.
Nonetheless, there were few and inconsistent data regarding the effects of gallic acid on platelet function.
Therefore, we designed this in vitro study to determine whether gallic acid could inhibit platelet activation and the possible mechanisms.
From our results, gallic acid could concentration-dependently inhibit platelet aggregation, P-selectin expression, and platelet-leukocyte aggregation.
Gallic acid prevented the elevation of intracellular calcium and attenuated phosphorylation of PKCα/p38 MAPK and Akt/GSK3β on platelets stimulated by the stimulants ADP or U46619.
This is the first mechanistic explanation for the inhibitory effects on platelets from gallic acid.
American Psychological Association (APA)
Chang, Shih-Sheng& Lee, Viola S. Y.& Tseng, Yu-Lun& Chang, Kuan-Cheng& Chen, Kuen-Bao& Chen, Yuh-Lien…[et al.]. 2012. Gallic Acid Attenuates Platelet Activation and Platelet-Leukocyte Aggregation: Involving Pathways of Akt and GSK3β. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028468
Modern Language Association (MLA)
Chang, Shih-Sheng…[et al.]. Gallic Acid Attenuates Platelet Activation and Platelet-Leukocyte Aggregation: Involving Pathways of Akt and GSK3β. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028468
American Medical Association (AMA)
Chang, Shih-Sheng& Lee, Viola S. Y.& Tseng, Yu-Lun& Chang, Kuan-Cheng& Chen, Kuen-Bao& Chen, Yuh-Lien…[et al.]. Gallic Acid Attenuates Platelet Activation and Platelet-Leukocyte Aggregation: Involving Pathways of Akt and GSK3β. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028468
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028468