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In Vitro Screening of Medicinal Plants Used in Mexico as Antidiabetics with Glucosidase and Lipase Inhibitory Activities
Joint Authors
Zavala-Sánchez, Miguel A.
Ramírez, Guillermo
Zamilpa, Alejandro
Pérez-Ramos, J.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This work shows the inhibitory effect on glucosidase and lipase enzymes of 23 medicinal plants described as traditional treatments for diabetes in several Mexican sources.
Hydroalcoholic extracts of selected plants were evaluated at 1 mg/mL for glucosidase and 0.25 mg/mL for lipase inhibitory activities, respectively.
Camellia sinensis, acarbose, and orlistat were used as positive controls.
Dose-response curves were done with the most active species.
Sixty percent of all tested extracts inhibited more than 25% of α-glucosidase activity.
C.
sinensis displayed an inhibition of 85% (IC50 = 299 μg/mL), while Ludwigia octovalvis and Iostephane heterophylla showed the highest inhibition (82.7 %, IC50 = 202 μg/mL and 60.6%, CI50 = 509 μg/mL, resp.).
With respect to lipase activity, L.
octovalvis and Tecoma stans were the most inhibiting treatments (31.4%, IC50 = 288 μg/mL; 27.2%, IC50 = 320 μg/mL), while C.
sinensis displayed 45% inhibition (IC50 = 310 μg/mL).
These results indicate that a high proportion of plants used in Mexico as treatment for diabetes displays significant inhibition of these digestive enzymes.
American Psychological Association (APA)
Ramírez, Guillermo& Zavala-Sánchez, Miguel A.& Pérez-Ramos, J.& Zamilpa, Alejandro. 2012. In Vitro Screening of Medicinal Plants Used in Mexico as Antidiabetics with Glucosidase and Lipase Inhibitory Activities. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1028484
Modern Language Association (MLA)
Ramírez, Guillermo…[et al.]. In Vitro Screening of Medicinal Plants Used in Mexico as Antidiabetics with Glucosidase and Lipase Inhibitory Activities. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1028484
American Medical Association (AMA)
Ramírez, Guillermo& Zavala-Sánchez, Miguel A.& Pérez-Ramos, J.& Zamilpa, Alejandro. In Vitro Screening of Medicinal Plants Used in Mexico as Antidiabetics with Glucosidase and Lipase Inhibitory Activities. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1028484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028484