Anxiolytic-Like Effects of Compound Zhi Zhu Xiang in Rats
Joint Authors
Wang, Yan-Li
Shi, Jin-Li
Yong, Liu
Ren, Zhao
Zhai, Yu-Jing
Guo, Jian-You
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The purpose of this study was to determine whether compound zhi zhu xiang (CZZX) exerts anxiolytic-like effects in rats.
The animals were orally administered CZZX (0.75, 1.5, and 3 g/kg daily) for 10 days and tested in the elevated plus maze (EPM), Vogel conflict test (VCT), and open field.
Repeated treatment with CZZX (3 g/kg/day, p.o.) significantly increased the percentage of both entries into and time spent on the open arms of the EPM compared with saline controls.
In the VCT, repeated treatment with CZZX (1.5 and 3 g/kg/day, p.o.) significantly increased the number of punished licks.
The drug did not change the total entries into the open arms of the EPM or interfere with water consumption or nociceptive threshold, discarding potential confounding factors in the two tests.
In the open field, locomotion was not reduced, discarding the possible sedative effect of CZZX.
In the binding assay, the binding of [3H] Ro 15-1788 (flumazenil) to the benzodiazepine binding site in washed crude synaptosomal membranes from rat cerebral cortex was affected by CZZX.
These data indicate an anxiolytic-like profile of action for CZZX without sedative side effects, and this activity may be mediated by benzodiazepine binding site modulation at γ-aminobutyric acid-A receptors.
American Psychological Association (APA)
Wang, Yan-Li& Shi, Jin-Li& Yong, Liu& Ren, Zhao& Zhai, Yu-Jing& Guo, Jian-You. 2012. Anxiolytic-Like Effects of Compound Zhi Zhu Xiang in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028485
Modern Language Association (MLA)
Wang, Yan-Li…[et al.]. Anxiolytic-Like Effects of Compound Zhi Zhu Xiang in Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028485
American Medical Association (AMA)
Wang, Yan-Li& Shi, Jin-Li& Yong, Liu& Ren, Zhao& Zhai, Yu-Jing& Guo, Jian-You. Anxiolytic-Like Effects of Compound Zhi Zhu Xiang in Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028485