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Effect of Alpinia katsumadai Hayata on House Dust Mite-Induced Atopic Dermatitis in NCNga Mice
Joint Authors
Shin, Hyeun-Kyoo
Seo, Chang-Seob
Lim, Hye-Sun
Lee, Hoyoung
Lee, Jun Kyoung
Lee, Mi-Young
Ha, Hyekyung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We evaluated the effects of Alpinia katsumadai Hayata (AKH, Zingiberaceae) extract on the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in RAW 264.7 cells, thymus- and-activation-regulated chemokine (TARC/CCL17) in HaCaT cells, and histamine level in HMC-1 cells.
In an in vivo experiment, atopic dermatitis was induced by topical application of house dust mites for 4 weeks, and the protective effects of AKH was investigated by measuring the severity of the skin reaction on the back and ears, and plasma levels of immunoglobulin E (IgE) and histamine.
AKH extract suppressed the production of NO and PGE2 in RAW 264.7 cells, TARC in HaCaT cells, and histamine in HMC-1 cells in a dose-dependent manner.
In in vivo experiments, the severity of dermatitis, including erythema/hemorrhage, edema, erosion and scaling, and plasma levels of IgE, and histamine were lower in NC/Nga mice with atopic dermatitis, treated with AKH extract than in untreated mice.
AKH extract reduced the histological manifestations of atopic dermatitis-like skin lesions such as erosion, hyperplasia of the epidermis and dermis, and inflammatory cell infiltration on the skin of the back and ear.
These results suggest that AKH inhibits the development of house dust mite-induced atopic dermatitis in NC/Nga mice.
American Psychological Association (APA)
Lim, Hye-Sun& Seo, Chang-Seob& Ha, Hyekyung& Lee, Hoyoung& Lee, Jun Kyoung& Lee, Mi-Young…[et al.]. 2012. Effect of Alpinia katsumadai Hayata on House Dust Mite-Induced Atopic Dermatitis in NCNga Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028490
Modern Language Association (MLA)
Lim, Hye-Sun…[et al.]. Effect of Alpinia katsumadai Hayata on House Dust Mite-Induced Atopic Dermatitis in NCNga Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028490
American Medical Association (AMA)
Lim, Hye-Sun& Seo, Chang-Seob& Ha, Hyekyung& Lee, Hoyoung& Lee, Jun Kyoung& Lee, Mi-Young…[et al.]. Effect of Alpinia katsumadai Hayata on House Dust Mite-Induced Atopic Dermatitis in NCNga Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028490
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028490