Morphologic and Pharmacological Investigations in the Epicatechin Gastroprotective Effect
Joint Authors
Akiko Hiruma-Lima, Clélia
Rozza, A. L.
Tanimoto, A.
Pellizzon, Cláudia Helena
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Previous studies of the gastroprotective activity of plants have highlighted the importance of the polyphenolic compound epicatechin (EC) in the treatment of gastric ulcers.
This paper aimed to evaluate and characterize the gastroprotective mechanism of action of EC using male rats.
The gastroprotective action of EC was analyzed in gastric ulcers induced by ethanol or indomethacin.
The involvement of sulfhydryl (SH) groups, K+ATP channels, α2 adrenoceptors, gastric antisecretory activity, and the amount of mucus in the development of gastric ulcers were investigated.
The lowest effective dose of EC providing gastroprotective effects was 50 mg/kg in the ethanol-induced gastric ulcers and 25 mg/kg in the indomethacin-induced gastric ulcers.
The gastroprotection seen upon treatment with EC was significantly decreased in rats pretreated with a SH compound reagent or an α2-receptor antagonist, but not with a K+ATP channel blocker.
Furthermore, oral treatment with EC increased mucus production and decreased H+ secretion.
Immunohistochemistry demonstrated the involvement of superoxide dismutase (SOD), nitric oxide (NO), and heat shock protein-70 (HSP-70) in the gastroprotection.
These results demonstrate that EC provides gastroprotection through reinforcement of the mucus barrier and neutralization of gastric juice and this protection occurs through the involvement of SH compounds, α2-adrenoceptors, NO, SOD, and HSP-70.
American Psychological Association (APA)
Rozza, A. L.& Akiko Hiruma-Lima, Clélia& Tanimoto, A.& Pellizzon, Cláudia Helena. 2012. Morphologic and Pharmacological Investigations in the Epicatechin Gastroprotective Effect. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028493
Modern Language Association (MLA)
Rozza, A. L.…[et al.]. Morphologic and Pharmacological Investigations in the Epicatechin Gastroprotective Effect. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028493
American Medical Association (AMA)
Rozza, A. L.& Akiko Hiruma-Lima, Clélia& Tanimoto, A.& Pellizzon, Cláudia Helena. Morphologic and Pharmacological Investigations in the Epicatechin Gastroprotective Effect. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028493