Zuonin B Inhibits Lipopolysaccharide-Induced Inflammation via Downregulation of the ERK12 and JNK Pathways in RAW264.7 Macrophages
Joint Authors
Yuk, Ji-Eun
Kwon, Ok-Kyung
Lee, Hyeong-Kyu
Oh, Sei-Ryang
Lee, Mee-Young
Ahn, Kyung-Seop
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We investigated whether Zuonin B exerts immunological effects on RAW264.7 cells.
Zuonin B, isolated from flower buds of Daphne genkwa, suppressed the levels of nitric oxide and prostaglandin E2, as well as proinflammatory cytokines, such as tumor necrosis factor-α and interleukin-(IL-) 6, in lipopolysaccharide-stimulated macrophages.
Moreover, the compound inhibited cyclooxygenase-2 and inducible nitric oxide synthase expression.
Zuonin B attenuated NF-kappaB (NF-κB) activation via suppressing proteolysis of inhibitor kappa B-alpha (IκB-α) and p65 nuclear translocation as well as phosphorylation of extracellular signal-regulated kinase 1/2 and c-Jun N-terminal kinase.
Additionally, IL-4 and IL-13 production in ConA-induced splenocytes was inhibited by Zuonin B.
In conclusion, the anti-inflammatory effects of Zuonin B are attributable to the suppression of proinflammatory cytokines and mediators via blockage of NF-κB and AP-1 activation.
Based on these findings, we propose that Zuonin B is potentially an effective functional chemical candidate for the prevention of inflammatory diseases.
American Psychological Association (APA)
Lee, Mee-Young& Yuk, Ji-Eun& Kwon, Ok-Kyung& Oh, Sei-Ryang& Lee, Hyeong-Kyu& Ahn, Kyung-Seop. 2012. Zuonin B Inhibits Lipopolysaccharide-Induced Inflammation via Downregulation of the ERK12 and JNK Pathways in RAW264.7 Macrophages. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028507
Modern Language Association (MLA)
Lee, Mee-Young…[et al.]. Zuonin B Inhibits Lipopolysaccharide-Induced Inflammation via Downregulation of the ERK12 and JNK Pathways in RAW264.7 Macrophages. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028507
American Medical Association (AMA)
Lee, Mee-Young& Yuk, Ji-Eun& Kwon, Ok-Kyung& Oh, Sei-Ryang& Lee, Hyeong-Kyu& Ahn, Kyung-Seop. Zuonin B Inhibits Lipopolysaccharide-Induced Inflammation via Downregulation of the ERK12 and JNK Pathways in RAW264.7 Macrophages. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028507
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028507