Chlorella sorokiniana-Induced Activation and Maturation of Human Monocyte-Derived Dendritic Cells through NF-κB and PI3KMAPK Pathways
Joint Authors
Lin, Li-Tsen
Ko, Ching-Huai
Chou, Nien-Tzu
Wu, Hsin-Chieh
Lai, Chin-Pen
Cheng, Chieh-Fang
Pan, I-Horng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Chlorella sorokiniana (CS) is a unicellular green alga.
The extracts of Chlorella have been used as treatments for relieving hypertension and modulating immune response.
The detailed mechanisms are not clear yet.
In this study, we sought to study the molecular mechanisms for the polysaccharide fraction of CS-induced immune response.
We pulsed dendritic cells (DCs) with CS and found that CS could maturate DCs.
CS-maturated DC could activate naïve T cells and stimulate T-cell proliferation and IFN-γ secretion.
Furthermore, CS activated PI3K and MAPKs signaling pathways in DCs by interacting with TLR4 receptor.
These CS-activated signaling pathways could further activate NF-κB and induce IL-12 production in DCs.
This study provides molecular mechanisms for CS-induced DCs activation and immune response.
American Psychological Association (APA)
Chou, Nien-Tzu& Cheng, Chieh-Fang& Wu, Hsin-Chieh& Lai, Chin-Pen& Lin, Li-Tsen& Pan, I-Horng…[et al.]. 2012. Chlorella sorokiniana-Induced Activation and Maturation of Human Monocyte-Derived Dendritic Cells through NF-κB and PI3KMAPK Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028513
Modern Language Association (MLA)
Chou, Nien-Tzu…[et al.]. Chlorella sorokiniana-Induced Activation and Maturation of Human Monocyte-Derived Dendritic Cells through NF-κB and PI3KMAPK Pathways. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1028513
American Medical Association (AMA)
Chou, Nien-Tzu& Cheng, Chieh-Fang& Wu, Hsin-Chieh& Lai, Chin-Pen& Lin, Li-Tsen& Pan, I-Horng…[et al.]. Chlorella sorokiniana-Induced Activation and Maturation of Human Monocyte-Derived Dendritic Cells through NF-κB and PI3KMAPK Pathways. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028513