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Effects of Extract from Solid-State Fermented Cordyceps sinensis on Type 2 Diabetes Mellitus
Joint Authors
Kan, Wei-Chih
Su, Shih-Bin
Wang, Hsien-Yi
Chien, Chih-Chiang
Li, Shun-Lai
Chen, Yu-Chun
Chang, Liang-Hao
Cheng, Chia-Hui
Tsai, Wan-Chen
Hwang, Jyh-Chang
Huang, Li-Hsueh
Chuu, Jiunn-Jye
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetes mellitus is the most common chronic disease in the world, and a wide range of drugs, including Chinese herbs, have been evaluated for the treatment of associated metabolic disorders.
This study investigated the potential hypoglycemic and renoprotective effects of an extract from the solid-state fermented mycelium of Cordyceps sinensis (CS).
We employed the KK/HIJ diabetic mouse model, in which the mice were provided with a high-fat diet for 8 weeks to induce hyperglycemia, followed by the administration of CS or rosiglitazone for 4 consecutive weeks.
Several parameters were evaluated, including changes in body weight, plasma lipid profiles, oral glucose tolerance tests, insulin tolerance tests, and plasma insulin concentrations.
Our results show that the CS extract significantly elevated HDL/LDL ratios at 4 weeks and decreased body weight gain at 8 weeks.
Interestingly, CS treatment did not lead to obvious improvements in hyperglycemia or resistance to insulin, while in vitro MTT assays indicated that CS protects pancreatic beta cells against the toxic effects of STZ.
CS also enhanced renal NKA activity and reduced the accumulation of mesangial matrix and collagen deposition.
In conclusion, CS extract can potentially preserve β-cell function and offer renoprotection, which may afford a promising therapy for DM.
American Psychological Association (APA)
Kan, Wei-Chih& Wang, Hsien-Yi& Chien, Chih-Chiang& Li, Shun-Lai& Chen, Yu-Chun& Chang, Liang-Hao…[et al.]. 2012. Effects of Extract from Solid-State Fermented Cordyceps sinensis on Type 2 Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028519
Modern Language Association (MLA)
Kan, Wei-Chih…[et al.]. Effects of Extract from Solid-State Fermented Cordyceps sinensis on Type 2 Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028519
American Medical Association (AMA)
Kan, Wei-Chih& Wang, Hsien-Yi& Chien, Chih-Chiang& Li, Shun-Lai& Chen, Yu-Chun& Chang, Liang-Hao…[et al.]. Effects of Extract from Solid-State Fermented Cordyceps sinensis on Type 2 Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028519
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028519