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Effectiveness of the Novel Herbal Medicine, KIOM-MA, and Its Bioconversion Product, KIOM-MA128, on the Treatment of Atopic Dermatitis
Joint Authors
Ma, Jin Yeul
Chung, Tae Ho
Kang, Tae Jin
Cho, Chang-Won
Im, Ga Young
Yang, Min Cheol
Lee, Geum Seon
Cho, Won-Kyung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
This study was conducted to determine if oral administration of the novel herbal medicine, KIOM-MA, and its Lactobacillus acidophilus-fermented product, KIOM-MA128, has therapeutic properties for the treatment of atopic dermatitis (AD).
Using AD-induced BALB/c mice by Ovalbumin and aluminum hydroxide, the effectiveness of KIOM-MA and KIOM-MA128 on AD was evaluated.
Oral administration of KIOM-MA and KIOM-MA128 reduced major clinical signs of AD including erythema/darkening, edema/papulation, excoriations, lichenification/prurigo, and dryness.
Interestingly, KIOM-MA128 more significantly improved AD-related symptoms including decrease of IgE level in the plasma as well as reduction of scratching behavior, skin severity in the AD BALB/c model.
HPLC analysis showed the significant changes in the constituent patterns between KIOM-MA and KIOM-MA128.
Our results suggest that both KIOM-MA and KIOM-MA128 have potential for therapeutic reagent for the treatment of AD, and further, the efficacy is significantly enhanced by L.
acidophilus fermentation via increases in its indicator molecule.
American Psychological Association (APA)
Chung, Tae Ho& Kang, Tae Jin& Cho, Won-Kyung& Im, Ga Young& Lee, Geum Seon& Yang, Min Cheol…[et al.]. 2012. Effectiveness of the Novel Herbal Medicine, KIOM-MA, and Its Bioconversion Product, KIOM-MA128, on the Treatment of Atopic Dermatitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028527
Modern Language Association (MLA)
Chung, Tae Ho…[et al.]. Effectiveness of the Novel Herbal Medicine, KIOM-MA, and Its Bioconversion Product, KIOM-MA128, on the Treatment of Atopic Dermatitis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028527
American Medical Association (AMA)
Chung, Tae Ho& Kang, Tae Jin& Cho, Won-Kyung& Im, Ga Young& Lee, Geum Seon& Yang, Min Cheol…[et al.]. Effectiveness of the Novel Herbal Medicine, KIOM-MA, and Its Bioconversion Product, KIOM-MA128, on the Treatment of Atopic Dermatitis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028527