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Antiasthmatic Effects of Herbal Complex MA and Its Fermented Product MA128
Joint Authors
Ma, Jin Yeul
Kim, Bok-Kyu
Kim, Seung-Hyung
Yang, Min Cheol
Kim, Dong-Seon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study was conducted to determine if oral administration of the novel herbal medicine, MA, and its Lactobacillus acidophilus fermented product, MA128, have therapeutic properties for the treatment of asthma.
Asthma was induced in BALB/c mice by systemic sensitization to ovalbumin (OVA) followed by intratracheal, intraperitoneal, and aerosol allergen challenges.
MA and MA128 were orally administered 6 times a week for 4 weeks.
At 1 day after the last ovalbumin exposure, airway hyperresponsiveness was assessed and samples of bronchoalveolar lavage fluid, lung cells, and serum were collected for further analysis.
We investigated the effect of MA and MA128 on airway hyperresponsiveness, pulmonary eosinophilic infiltration, various immune cell phenotypes, Th2 cytokine production, OVA-specific IgE production, and Th1/Th2 cytokine production in this mouse model of asthma.
In BALB/c mice, we found that MA and MA128 treatment suppressed eosinophil infiltration into airways and blood, allergic airway inflammation and AHR by suppressing the production of IL-5, IL-13, IL-17, Eotaxin, and OVA-specific IgE, by upregulating the production of OVA-specific Th1 cytokine (IFN-γ), and by downregulating OVA-specific Th2 cytokine (IL-4) in the culture supernatant of spleen cells.
The effectiveness of MA was increased by fermentation with Lactobacillus acidophilus.
American Psychological Association (APA)
Kim, Dong-Seon& Kim, Seung-Hyung& Kim, Bok-Kyu& Yang, Min Cheol& Ma, Jin Yeul. 2011. Antiasthmatic Effects of Herbal Complex MA and Its Fermented Product MA128. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028528
Modern Language Association (MLA)
Kim, Dong-Seon…[et al.]. Antiasthmatic Effects of Herbal Complex MA and Its Fermented Product MA128. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1028528
American Medical Association (AMA)
Kim, Dong-Seon& Kim, Seung-Hyung& Kim, Bok-Kyu& Yang, Min Cheol& Ma, Jin Yeul. Antiasthmatic Effects of Herbal Complex MA and Its Fermented Product MA128. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028528