Herbal Formula, PM014, Attenuates Lung Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease
Joint Authors
Kim, Youngeun
Kim, Hye Jin
Jung, Sungki
Jung, Heejae
Bae, Hyunsu
Park, Soojin
Jang, Young Pyo
Lee, Hyojung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Chronic obstructive pulmonary disease (COPD), which is characterized by airway obstruction, leads to, as the two major forms of COPD, chronic bronchitis and emphysema.
This study was conducted to evaluate the effects of herbal formula, PM014, in a murine model of COPD.
Balb/c mice were treated once with each herb extract in PM014 or PM014 mixture via an oral injection.
Lipopolysaccharide (LPS) or elastase/LPS were administrated to the mice to induce a disease that resembles COPD.
PM014 treatment significantly attenuated the increased accumulation of immune cells in bronchoalveolar lavage fluid (BALF) compared to control mice.
In addition, the TNF-α and IL-6 levels in BALF were decreased in the PM014 mice.
Furthermore, histological analysis demonstrated that PM014 attenuated the hazardous effects of lung inflammation.
These data suggest that PM014 exerts beneficial effects against forms of COPD such as lung inflammation.
American Psychological Association (APA)
Lee, Hyojung& Kim, Youngeun& Kim, Hye Jin& Park, Soojin& Jang, Young Pyo& Jung, Sungki…[et al.]. 2012. Herbal Formula, PM014, Attenuates Lung Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028529
Modern Language Association (MLA)
Lee, Hyojung…[et al.]. Herbal Formula, PM014, Attenuates Lung Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028529
American Medical Association (AMA)
Lee, Hyojung& Kim, Youngeun& Kim, Hye Jin& Park, Soojin& Jang, Young Pyo& Jung, Sungki…[et al.]. Herbal Formula, PM014, Attenuates Lung Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028529
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028529