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NBM-HD-1: A Novel Histone Deacetylase Inhibitor with Anticancer Activity
Joint Authors
Liang, Yu-Chih
Chuang, Shuang-En
Huang, Chung-Yang
Huang, Wei-Jan
Chi, Li-Ling
Lee, Chi-Yun
Lin, Chia-Wei
Chen, Ai-Ling
Chiu, Chun-Jung
Lee, Cheng-Feng
Huang, Jing-Shi
Chen, Chia-Nan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
HDAC inhibitors (HDACis) have been developed as promising anticancer agents in recent years.
In this study, we synthesized and characterized a novel HDACi, termed NBM-HD-1.
This agent was derived from the semisynthesis of propolin G, isolated from Taiwanese green propolis (TGP), and was shown to be a potent suppressor of tumor cell growth in human breast cancer cells (MCF-7 and MDA-MB-231) and rat glioma cells (C6), with an IC50 ranging from 8.5 to 10.3 μM.
Western blot demonstrated that levels of p21(Waf1/Cip1), gelsolin, Ac-histone 4, and Ac-tubulin markedly increased after treatment of cancer cells with NBM-HD-1.
After NBM-HD-1 treatment for 1–4 h, p-PTEN and p-AKT levels were markedly decreased.
Furthermore, we also found the anticancer activities of NBM-HD-1 in regulating cell cycle regulators.
Treatment with NBM-HD-1, p21(Waf1/Cip1) gene expression had markedly increased while cyclin B1 and D1 gene expressions had markedly decreased.
On the other hand, we found that NBM-HD-1 increased the expressions of tumor-suppressor gene p53 in a dose-dependent manner.
Finally, we showed that NBM-HD-1 exhibited potent antitumor activity in a xenograft model.
In conclusion, this study demonstrated that this compound, NBM-HD-1, is a novel and potent HDACi with anticancer activity in vitro and in vivo.
American Psychological Association (APA)
Huang, Wei-Jan& Liang, Yu-Chih& Chuang, Shuang-En& Chi, Li-Ling& Lee, Chi-Yun& Lin, Chia-Wei…[et al.]. 2011. NBM-HD-1: A Novel Histone Deacetylase Inhibitor with Anticancer Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028532
Modern Language Association (MLA)
Huang, Wei-Jan…[et al.]. NBM-HD-1: A Novel Histone Deacetylase Inhibitor with Anticancer Activity. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028532
American Medical Association (AMA)
Huang, Wei-Jan& Liang, Yu-Chih& Chuang, Shuang-En& Chi, Li-Ling& Lee, Chi-Yun& Lin, Chia-Wei…[et al.]. NBM-HD-1: A Novel Histone Deacetylase Inhibitor with Anticancer Activity. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028532
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028532