Influence of Fructooligosaccharide on Pharmacokinetics of Isoflavones in Postmenopausal Women
Joint Authors
Sangdee, Chaichan
Techatoei, Sujitra
Rojanasthien, Noppamas
Teekachunhatean, Supanimit
Manorot, Maleeya
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The objective of the present paper was to determine the influence of fructooligosaccharide (FOS) on the pharmacokinetics of isoflavones in healthy postmenopausal women.
The study was a fixed-sequence, two-phase, crossover study.
Twelve subjects received a single oral dose of 300 mL of a soy beverage.
Blood samples were collected before the dose and at 0.5, 1, 2, 4, 6, 8, 10, 12, 24, and 32 h after the administration of the soy beverage.
After a washout period of at least 1 week, subjects were assigned to receive oral doses of FOS, 5 g each time, twice a day (after breakfast and dinner) for 14 days, followed by a single oral dose of the same soy beverage on the next day.
Blood samples were then collected at the same time points mentioned previously.
Plasma isoflavone concentrations were determined by HPLC.
Continuous oral administrations of FOS followed by a single oral administration of soy beverage caused significant increases in Cmax, AUC0–32, and AUC0–∞ of genistein and AUC0–32 of daidzein, comparing to those obtained following a single oral dose of soy beverage alone.
Other pharmacokinetic parameters (Tmax and t1/2 of both aglycones and AUC0–∞ of daidzein) between both regimens were not significantly different.
American Psychological Association (APA)
Teekachunhatean, Supanimit& Techatoei, Sujitra& Rojanasthien, Noppamas& Manorot, Maleeya& Sangdee, Chaichan. 2012. Influence of Fructooligosaccharide on Pharmacokinetics of Isoflavones in Postmenopausal Women. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028534
Modern Language Association (MLA)
Teekachunhatean, Supanimit…[et al.]. Influence of Fructooligosaccharide on Pharmacokinetics of Isoflavones in Postmenopausal Women. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028534
American Medical Association (AMA)
Teekachunhatean, Supanimit& Techatoei, Sujitra& Rojanasthien, Noppamas& Manorot, Maleeya& Sangdee, Chaichan. Influence of Fructooligosaccharide on Pharmacokinetics of Isoflavones in Postmenopausal Women. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028534