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Mechanisms of Gastroprotective Effects of Ethanolic Leaf Extract of Jasminum sambac against HClEthanol-Induced Gastric Mucosal Injury in Rats
Joint Authors
Salama, Suzy M.
Mohamed Elhassan Taha, Manal
Alkiyumi, Salim S.
Hussiani, Jamal
Asykin, Nur
Abdel Wahab, Siddig Ibrahim
AlRashdi, Ahmed S.
Abdulla, Mahmood Ameen
Hadi, A. Hamid A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-05
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Jasminum sambac is used in folk medicine as the treatment of many diseases.
The aim of the present investigation is to evaluate the gastroprotective effects of ethanolic extracts of J.
sambac leaves against acidified ethanol-induced gastric ulcers in rats.
Seven groups of rats were orally pre-treated with carboxymethylcellulose (CMC) as normal group, CMC as ulcer group, 20 mg/kg of omeprazole as positive group, 62.5, 125, 250, and 500 mg/kg of extract as the experimental groups, respectively.
An hour later, CMC was given orally to normal group and acidified ethanol solution was given orally to the ulcer control, positive control, and the experimental groups.
The rats were sacrificed after an hour later.
Acidity of gastric content, the gastric wall mucus, ulcer areas, and histology and immunohistochemistry of the gastric wall were assessed.
Gastric homogenates were determined for prostaglandin E2 (PGE2), superoxide dismutase (SOD), andmalondialdehyde (MDA) content.
Ulcer group exhibited significantly severe mucosal injury as compared with omeprazole or extract which shows significant protection towards gastric mucosal injury the plant promotes ulcer protection as it shows significant reduction of ulcer area grossly, and histology showed marked reduction of edema and leucocytes infiltration of submucosal layer compared with ulcer group.
Immunohistochemistry showed overexpression of Hsp70 protein and downexpression of Bax protein in rats pretreated with extract.
Significant increased in the pH, mucus of gastric content and high levels of PGE2, SOD and reduced amount of MDA was observed.
American Psychological Association (APA)
AlRashdi, Ahmed S.& Salama, Suzy M.& Alkiyumi, Salim S.& Abdulla, Mahmood Ameen& Hadi, A. Hamid A.& Abdel Wahab, Siddig Ibrahim…[et al.]. 2012. Mechanisms of Gastroprotective Effects of Ethanolic Leaf Extract of Jasminum sambac against HClEthanol-Induced Gastric Mucosal Injury in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1028537
Modern Language Association (MLA)
AlRashdi, Ahmed S.…[et al.]. Mechanisms of Gastroprotective Effects of Ethanolic Leaf Extract of Jasminum sambac against HClEthanol-Induced Gastric Mucosal Injury in Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-1028537
American Medical Association (AMA)
AlRashdi, Ahmed S.& Salama, Suzy M.& Alkiyumi, Salim S.& Abdulla, Mahmood Ameen& Hadi, A. Hamid A.& Abdel Wahab, Siddig Ibrahim…[et al.]. Mechanisms of Gastroprotective Effects of Ethanolic Leaf Extract of Jasminum sambac against HClEthanol-Induced Gastric Mucosal Injury in Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1028537
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028537