Changes in Cytokine Expression after Electroacupuncture in Neuropathic Rats
Joint Authors
Lee, Hyejung
Cha, Myeoung Hoon
Nam, Taick Sang
Kwak, Yongho
Lee, Bae Hwan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The production of proinflammatory cytokines including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) plays a key role in chronic pain such as neuropathic pain.
We investigated changes in cytokine expression in injured peripheral nerves and dorsal root ganglia (DRG) following electroacupuncture (EA) treatment.
Neuropathic pain was induced by peripheral nerve injury to the left hind limb of Sprague-Dawley rats under pentobarbital anesthesia.
Two weeks later, the nerve-injured rats were treated by EA for 10 minutes.
The expression levels of IL-1β, IL-6, and TNF-α in peripheral nerves and DRG of neuropathic rats were significantly increased in nerve-injured rats.
However, after EA, the cytokine expression levels were noticeably decreased in peripheral nerves and DRG.
These results suggest that EA stimulation can reduce the levels of proinflamtory cytokines elevated after nerve injury.
American Psychological Association (APA)
Cha, Myeoung Hoon& Nam, Taick Sang& Kwak, Yongho& Lee, Hyejung& Lee, Bae Hwan. 2012. Changes in Cytokine Expression after Electroacupuncture in Neuropathic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1028540
Modern Language Association (MLA)
Cha, Myeoung Hoon…[et al.]. Changes in Cytokine Expression after Electroacupuncture in Neuropathic Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1028540
American Medical Association (AMA)
Cha, Myeoung Hoon& Nam, Taick Sang& Kwak, Yongho& Lee, Hyejung& Lee, Bae Hwan. Changes in Cytokine Expression after Electroacupuncture in Neuropathic Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1028540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028540