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Electroacupuncture at PC6 (Neiguan) Improves Extracellular Signal-Regulated Kinase Signaling Pathways Through the Regulation of Neuroendocrine Cytokines in Myocardial Hypertrophic Rats
Joint Authors
Liang, Fengxia
Wang, Hua
Li, Jia
Li, Jing
Hong, Yaqun
Wu, Song
Tang, Hongtu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Electroacupuncture (EA) therapy has been widely accepted as a useful therapeutic technique with low or no risk in the clinical prevention of cardiac hypertrophy.
However, the signaling transduction mechanism underlying this effect remains unclear.
The current study investigates the effects of EA on the signaling pathways of myocardial hypertrophy (MH) in rats.
Up to 40 3-month-old Sprague-Dawley (SD) rats were randomly divided into normal, model, PC6 (Neiguan), and LI4 (Hegu) groups, with ten rats in each group.
All the rats except for the normal group received 3 mg/kg·d of isoprinosine hydrochloride (ISO) injection into the back skin.
The rats in the PC6 and LI4 groups received EA for 14 days.
On the 15th day, electrocardiograms were recorded, and the ultrastructure of the myocardial cells was observed.
The myocardial hypertrophy indices (MHIs), electrocardiograph (ECG), ultrastructure observation, levels of plasma angiotensin II (Ang II) and endothelin (ET), as well as protein expression of extracellular signal-regulated kinase (ERK), and phosphorylation extracellular signal regulating kinase (p-ERK) in the left ventricular myocardial tissue were measured.
The results indicated that EA can improve cardiac function in MH rats by modulating upstream neuroendocrine cytokines that regulate the ERK signaling pathways.
American Psychological Association (APA)
Li, Jia& Li, Jing& Liang, Fengxia& Hong, Yaqun& Wu, Song& Tang, Hongtu…[et al.]. 2011. Electroacupuncture at PC6 (Neiguan) Improves Extracellular Signal-Regulated Kinase Signaling Pathways Through the Regulation of Neuroendocrine Cytokines in Myocardial Hypertrophic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028541
Modern Language Association (MLA)
Li, Jia…[et al.]. Electroacupuncture at PC6 (Neiguan) Improves Extracellular Signal-Regulated Kinase Signaling Pathways Through the Regulation of Neuroendocrine Cytokines in Myocardial Hypertrophic Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028541
American Medical Association (AMA)
Li, Jia& Li, Jing& Liang, Fengxia& Hong, Yaqun& Wu, Song& Tang, Hongtu…[et al.]. Electroacupuncture at PC6 (Neiguan) Improves Extracellular Signal-Regulated Kinase Signaling Pathways Through the Regulation of Neuroendocrine Cytokines in Myocardial Hypertrophic Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028541
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028541