Potential Therapeutic Role of Z-Isochaihulactone in Lung Cancer through Induction of Apoptosis via Notch Signaling
Joint Authors
Ou, Jie-Ping
Lin, Hsueh-Yi
Tseng, I.-Hsuan
Chen, Cheng-Jueng
Hsu, Hui-Chen
Chan, De-Chuan
Yu, Sung-Liang
Chen, Yi-Lin Sophia
Su, Kang-Yi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Lung cancer is one of the leading causes of cancer death in worldwide and required for novel therapeutic strategy.
Our previous research demonstrated that the crude acetone extract of Bupleurum scorzonerifolium (BS-AE) and its component isochaihulactone induce antiproliferative and apoptotic effects on the lung adenocarcinoma cell line.
Structural analysis has identified isochaihulactone as a lignan, with a chiral center and two racemic forms (Z-isochaihulactone and E-isochaihulactone).
In this study, Z-isochaihulactone displayed significantly higher tumor cytotoxicity than E-isochaihulactone in A549 cells.
The notch signaling pathway plays a pivotal role in determination of cell fate during development, while in lung cancer, it might have oncogenic or tumor-suppressive controversial functions.
We showed that Z-isochaihulactone induced morphological changes in the A549 cells, inhibited cell growth, and arrested the cell cycle at the G2/M phase.
It also induced upregulation of the active form of Notch1 (notch intracellular domain, NICD), which further induced p21 and c-Myc expression in time- and dose-dependent manners.
Administrations of Z-isochaihulactone in nude mice can significantly inhibit tumor growth due to enhancement of NICD expression confirmed by immunohistochemical analysis.
Taken together, our results supported that Z-isochaihulactone can efficiently inhibit tumorigenicity and be a potential compound for therapy.
American Psychological Association (APA)
Ou, Jie-Ping& Lin, Hsueh-Yi& Su, Kang-Yi& Yu, Sung-Liang& Tseng, I.-Hsuan& Chen, Cheng-Jueng…[et al.]. 2012. Potential Therapeutic Role of Z-Isochaihulactone in Lung Cancer through Induction of Apoptosis via Notch Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028550
Modern Language Association (MLA)
Ou, Jie-Ping…[et al.]. Potential Therapeutic Role of Z-Isochaihulactone in Lung Cancer through Induction of Apoptosis via Notch Signaling. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028550
American Medical Association (AMA)
Ou, Jie-Ping& Lin, Hsueh-Yi& Su, Kang-Yi& Yu, Sung-Liang& Tseng, I.-Hsuan& Chen, Cheng-Jueng…[et al.]. Potential Therapeutic Role of Z-Isochaihulactone in Lung Cancer through Induction of Apoptosis via Notch Signaling. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028550
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028550