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Antimigratory Effects of the Methanol Extract from Momordica charantia on Human Lung Adenocarcinoma CL1 Cells
Joint Authors
Chuang, Shuang-En
Li, Chia-Jung
Tsang, Shih-Fang
Chyuan, Jong-Ho
Hsu, Hsue-Yin
Lin, Jung-Hsuan
Tsai, Chun-Hao
Chiu, Shu-Jun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Momordica charantia has been found to exhibit anticancer activity, in addition to its well-known therapeutic functions.
We have demonstrated that the leaf extract of Momordica charantia (MCME) induces apoptosis in several human cancer cells through caspase- and mitochondria-dependent pathways.
In this study, a different susceptibility to MCME was found in human lung adenocarcinoma CL1 cells with different metastatic ability, leading to the significant difference of cell viability and invasiveness between MCME-treated CL1-0 and CL1-5 cells.
MCME was found to upregulate the expression of Wnt-2 and affect the migratory and invasive ability of CL1 cells through suppressed MMP-2 and MMP-9 enzymatic activities.
We proposed that MCME mediates inhibition against migration of CL1 cells by reducing the expression and activation of Src and FAK to decrease the expression of downstream Akt, β-catenin, and MMPs.
American Psychological Association (APA)
Hsu, Hsue-Yin& Lin, Jung-Hsuan& Li, Chia-Jung& Tsang, Shih-Fang& Tsai, Chun-Hao& Chyuan, Jong-Ho…[et al.]. 2012. Antimigratory Effects of the Methanol Extract from Momordica charantia on Human Lung Adenocarcinoma CL1 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028560
Modern Language Association (MLA)
Hsu, Hsue-Yin…[et al.]. Antimigratory Effects of the Methanol Extract from Momordica charantia on Human Lung Adenocarcinoma CL1 Cells. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1028560
American Medical Association (AMA)
Hsu, Hsue-Yin& Lin, Jung-Hsuan& Li, Chia-Jung& Tsang, Shih-Fang& Tsai, Chun-Hao& Chyuan, Jong-Ho…[et al.]. Antimigratory Effects of the Methanol Extract from Momordica charantia on Human Lung Adenocarcinoma CL1 Cells. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028560