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Toxicological Features of Catha edulis (Khat) on Livers and Kidneys of Male and Female Sprague-Dawley Rats: A Subchronic Study
Joint Authors
Abdulla, Mahmood Ameen
Alsalahi, Abdulsamad
Al-Mamary, Mohammed
Abdelwahab, Siddig Ibrahim
Alabsi, Aied M.
Shwter, Abdrabuh
Noordin, Mohamed Ibrahim
Alshawsh, Mohammed A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hepato- and nephrotoxicity of Khat consumption (Catha edulis Forskal) have been evoked.
Therefore, this study was conducted to evaluate such possible hepatorenal toxicity in female and male Sprague-Dawley rats (SD rats) focusing primarily on liver and kidney.
In addition, female and male rats were investigated separately.
Accordingly, forty-eight SD-rats (100–120 g) were distributed randomly into four groups of males and female (n=12).
Normal controls (NCs) received distilled water, whereas test groups received 500 mg/kg (low dose (LD)), 1000 mg/kg (medium dose (MD)), or 2000 mg/kg (high dose (HD)) of crude extract of Catha edulis orally for 4 weeks.
Then, physical, biochemical, hematological, and histological parameters were analyzed.
Results in Khat-fed rats showed hepatic enlargement, abnormal findings in serum aspartate aminotransferase (AST), and alkaline phosphatase (ALP) of male and female SD-rats and serum albumin (A) and serum creatinine (Cr) of female as compared to controls.
In addition, histopathological abnormalities confirmed hepatic and renal toxicities of Khat that were related to heavy Khat consumption.
In summary, Khat could be associated with hepatic hypertrophy and hepatotoxicity in male and female SD-rats and nephrotoxicity only in female SD-rats.
American Psychological Association (APA)
Alsalahi, Abdulsamad& Abdulla, Mahmood Ameen& Al-Mamary, Mohammed& Noordin, Mohamed Ibrahim& Abdelwahab, Siddig Ibrahim& Alabsi, Aied M.…[et al.]. 2012. Toxicological Features of Catha edulis (Khat) on Livers and Kidneys of Male and Female Sprague-Dawley Rats: A Subchronic Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028568
Modern Language Association (MLA)
Alsalahi, Abdulsamad…[et al.]. Toxicological Features of Catha edulis (Khat) on Livers and Kidneys of Male and Female Sprague-Dawley Rats: A Subchronic Study. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028568
American Medical Association (AMA)
Alsalahi, Abdulsamad& Abdulla, Mahmood Ameen& Al-Mamary, Mohammed& Noordin, Mohamed Ibrahim& Abdelwahab, Siddig Ibrahim& Alabsi, Aied M.…[et al.]. Toxicological Features of Catha edulis (Khat) on Livers and Kidneys of Male and Female Sprague-Dawley Rats: A Subchronic Study. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028568