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The Antiparkinsonian and Antidyskinetic Mechanisms of Mucuna pruriens in the MPTP-Treated Nonhuman Primate
Joint Authors
Lieu, Christopher A.
Venkiteswaran, Kala
Rao, Anand N.
Petticoffer, Andrew C.
Gilbert, Erin V.
Deogaonkar, Milind
Manyam, Bala V.
Subramanian, Thyagarajan
Gilmour, Timothy P.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Chronic treatment with levodopa (LD) in Parkinson's disease (PD) can cause drug induced dyskinesias.
Mucuna pruriens endocarp powder (MPEP) contains several compounds including natural LD and has been reported to not cause drug-induced dyskinesias.
We evaluated the effects of Mucuna pruriens to determine if its underlying mechanistic actions are exclusively due to LD.
We first compared MPEP with and without carbidopa (CD), and LD+CD in hemiparkinsonian (HP) monkeys.
Each treatment ameliorated parkinsonism.
We then compared the neuronal firing properties of the substantia nigra reticulata (SNR) and subthalamic nucleus (STN) in HP monkeys with MPEP+CD and LD+CD to evaluate basal ganglia circuitry alterations.
Both treatments decreased SNR firing rate compared to HP state.
However, LD+CD treatments significantly increased SNR bursting firing patterns that were not seen with MPEP+CD treatments.
No significant changes were seen in STN firing properties.
We then evaluated the effects of a water extract of MPEP.
Oral MPWE ameliorated parkinsonism without causing drug-induced dyskinesias.
The distinctive neurophysiological findings in the basal ganglia and the ability to ameliorate parkinsonism without causing dyskinesias strongly suggest that Mucuna pruriens acts through a novel mechanism that is different from that of LD.
American Psychological Association (APA)
Lieu, Christopher A.& Venkiteswaran, Kala& Gilmour, Timothy P.& Rao, Anand N.& Petticoffer, Andrew C.& Gilbert, Erin V.…[et al.]. 2012. The Antiparkinsonian and Antidyskinetic Mechanisms of Mucuna pruriens in the MPTP-Treated Nonhuman Primate. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028578
Modern Language Association (MLA)
Lieu, Christopher A.…[et al.]. The Antiparkinsonian and Antidyskinetic Mechanisms of Mucuna pruriens in the MPTP-Treated Nonhuman Primate. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028578
American Medical Association (AMA)
Lieu, Christopher A.& Venkiteswaran, Kala& Gilmour, Timothy P.& Rao, Anand N.& Petticoffer, Andrew C.& Gilbert, Erin V.…[et al.]. The Antiparkinsonian and Antidyskinetic Mechanisms of Mucuna pruriens in the MPTP-Treated Nonhuman Primate. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028578
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028578