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Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing
Joint Authors
Mohd Zohdi, Rozaini
Yusof, Norimah
Mohamed Mustapha, Noordin
Abdullah, Muhammad Nazrul Hakim
Abu Bakar Zakaria, Md Zuki
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A novel cross-linked honey hydrogel dressing was developed by incorporating Malaysian honey into hydrogel dressing formulation, cross-linked and sterilized using electron beam irradiation (25 kGy).
In this study, the physical properties of the prepared honey hydrogel and its wound healing efficacy on deep partial thickness burn wounds in rats were assessed.
Skin samples were taken at 7, 14, 21, and 28 days after burn for histopathological and molecular evaluations.
Application of honey hydrogel dressings significantly enhanced (P<0.05) wound closure and accelerated the rate of re-epithelialization as compared to control hydrogel and OpSite film dressing.
A significant decrease in inflammatory response was observed in honey hydrogel treated wounds as early as 7 days after burn (P<0.05).
Semiquantitative analysis using RT-PCR revealed that treatment with honey hydrogel significantly (P<0.05) suppressed the expression of proinflammatory cytokines (IL-1α, IL-1β, and IL-6).
The present study substantiates the potential efficacy of honey hydrogel dressings in accelerating burn wound healing.
American Psychological Association (APA)
Mohd Zohdi, Rozaini& Abu Bakar Zakaria, Md Zuki& Yusof, Norimah& Mohamed Mustapha, Noordin& Abdullah, Muhammad Nazrul Hakim. 2011. Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028579
Modern Language Association (MLA)
Mohd Zohdi, Rozaini…[et al.]. Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028579
American Medical Association (AMA)
Mohd Zohdi, Rozaini& Abu Bakar Zakaria, Md Zuki& Yusof, Norimah& Mohamed Mustapha, Noordin& Abdullah, Muhammad Nazrul Hakim. Gelam (Melaleuca spp.) Honey-Based Hydrogel as Burn Wound Dressing. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028579
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028579