![](/images/graphics-bg.png)
Metabolic Profiling Study of Yang Deficiency Syndrome in Hepatocellular Carcinoma by H1 NMR and Pattern Recognition
Joint Authors
Ling, Changquan
Huang, Xueqiang
Chen, Qunwei
Yang, Genjin
Dai, Weixing
Lang, Qingbo
Du, Juan
Yan, Shikai
Zhang, Weidong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study proposes a 1H NMR-based metabonomic approach to explore the biochemical characteristics of Yang deficiency syndrome in hepatocellular carcinoma (HCC) based on serum metabolic profiling.
Serum samples from 21 cases of Yang deficiency syndrome HCC patients (YDS-HCC) and 21 cases of non-Yang deficiency syndrome HCC patients (NYDS-HCC) were analyzed using 1H NMR spectroscopy and partial least squares discriminant analysis (PLS-DA) was applied to visualize the variation patterns in metabolic profiling of sera from different groups.
The differential metabolites were identified and the biochemical characteristics were analyzed.
We found that the intensities of six metabolites (LDL/VLDL, isoleucine, lactate, lipids, choline, and glucose/sugars) in serum of Yang deficiency syndrome patients were lower than those of non-Yang deficiency syndrome patients.
It implies that multiple metabolisms, mainly including lipid, amino acid, and energy metabolisms, are unbalanced or weakened in Yang deficiency syndrome patients with HCC.
The decreased intensities of metabolites including LDL/VLDL, isoleucine, lactate, lipids, choline, and glucose/sugars in serum may be the distinctive metabolic variations of Yang deficiency syndrome patients with HCC.
And these metabolites may be potential biomarkers for diagnosis of Yang deficiency syndrome in HCC.
American Psychological Association (APA)
Huang, Xueqiang& Chen, Qunwei& Yang, Genjin& Dai, Weixing& Lang, Qingbo& Du, Juan…[et al.]. 2012. Metabolic Profiling Study of Yang Deficiency Syndrome in Hepatocellular Carcinoma by H1 NMR and Pattern Recognition. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1028580
Modern Language Association (MLA)
Huang, Xueqiang…[et al.]. Metabolic Profiling Study of Yang Deficiency Syndrome in Hepatocellular Carcinoma by H1 NMR and Pattern Recognition. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1028580
American Medical Association (AMA)
Huang, Xueqiang& Chen, Qunwei& Yang, Genjin& Dai, Weixing& Lang, Qingbo& Du, Juan…[et al.]. Metabolic Profiling Study of Yang Deficiency Syndrome in Hepatocellular Carcinoma by H1 NMR and Pattern Recognition. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1028580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028580