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Towards Modernization of the Formulation of the Traditional Uighur Medicine Herbal Preparation Abnormal Savda Munziq
Joint Authors
Popescu, Ruxandra
Singhuber, Judith
Kizaibek, Murat
Prinz, Sonja
Kopp, B.
Halmurati, Upur
Zehl, M.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Abnormal Savda Munziq (ASMq) is a herbal preparation used in Traditional Uighur Medicine for the treatment and prevention of diabetes, cardiovascular diseases, chronic asthma and cancer.
The recommended dose of this decoction for cancer patients is 500 mL administered orally three times a day.
Our approach aimed at reducing the high amount of fluid intake required by fractionation of ASMq guided by the antiproliferative activity on HL-60 cells.
The fractionation of ASMq resulted in the preparation of an active extract, Extr-4.
Using solid phase extraction, Extr-4 was further fractionated into five fractions (SPE-0, SPE-20, SPE-40, SPE-60 and SPE-80), with SPE-40 showing the strongest antiproliferative activity.
Caffeic acid, rutin, isoquercitrin, isorhamnetin 3-O-rutinoside, apigenin 7-O-glucoside, rosmarinic acid, luteolin and formononetin were identified in Extr-4 and fractions thereof by means of TLC, HPLC-DAD and LC-MS.
SPE-40 contained the main compounds responsible for the antiproliferative activity on HL-60 cells.
Thus, a phenolic fraction with high antiproliferative activity on HL-60 cells was obtained from ASMq through the bioassay-guided fractionation process.
This could provide a better pharmaceutical formulation that minimizes the administration inconveniencies of a high volume (1.5 L per day) of ASMq decoction for cancer patients.
American Psychological Association (APA)
Kizaibek, Murat& Popescu, Ruxandra& Prinz, Sonja & Halmurati, Upur& Singhuber, Judith& Zehl, M.…[et al.]. 2011. Towards Modernization of the Formulation of the Traditional Uighur Medicine Herbal Preparation Abnormal Savda Munziq. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028592
Modern Language Association (MLA)
Kizaibek, Murat…[et al.]. Towards Modernization of the Formulation of the Traditional Uighur Medicine Herbal Preparation Abnormal Savda Munziq. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028592
American Medical Association (AMA)
Kizaibek, Murat& Popescu, Ruxandra& Prinz, Sonja & Halmurati, Upur& Singhuber, Judith& Zehl, M.…[et al.]. Towards Modernization of the Formulation of the Traditional Uighur Medicine Herbal Preparation Abnormal Savda Munziq. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028592
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028592