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Melanogenesis Inhibitor(s) from Phyla nodiflora Extract
Joint Authors
Wang, M.-C.
Yen, Feng-Lin
Liang, Chan-Jung
Lee, Chiang-Wen
Ko, Horng-Huey
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Overexpression of tyrosinase can cause excessive production of melanin and lead to hyperpigmentation disorders, including melasma and freckles.
Recently, agents obtained from plants are being used as alternative medicines to downregulate tyrosinase synthesis and decrease melanin production.
Phyla nodiflora Greene (Verbenaceae) is used as a folk medicine in Taiwanese for treating and preventing inflammatory diseases such as hepatitis and dermatitis.
However, the antimelanogenesis activity and molecular biological mechanism underlying the activity of the methanolic extract of P.
nodiflora (PNM) have not been investigated to date.
Our results showed that PNM treatment was not cytotoxic and significantly reduced the cellular melanin content and tyrosinase activity in a dose-dependent manner (P<0.05).
Further, PNM exhibited a significant antimelanogenesis effect (P<0.05) by reducing the levels of phospho-cAMP response element-binding protein and microphthalmia-associated transcription factor (MITF), inhibiting the synthesis of tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2, and decreasing the cellular melanin content.
Moreover, PNM significantly activated the phosphorylation of mitogen-activated protein kinases, including phospho-extracellular signal-regulated kinase, c-Jun N-terminal kinase, and phospho-p38, and inhibited the synthesis of MITF, thus decreasing melanogenesis.
These properties suggest that PNM could be used as a clinical and cosmetic skin-whitening agent to cure and/or prevent hyperpigmentation.
American Psychological Association (APA)
Yen, Feng-Lin& Wang, M.-C.& Liang, Chan-Jung& Ko, Horng-Huey& Lee, Chiang-Wen. 2012. Melanogenesis Inhibitor(s) from Phyla nodiflora Extract. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028594
Modern Language Association (MLA)
Yen, Feng-Lin…[et al.]. Melanogenesis Inhibitor(s) from Phyla nodiflora Extract. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028594
American Medical Association (AMA)
Yen, Feng-Lin& Wang, M.-C.& Liang, Chan-Jung& Ko, Horng-Huey& Lee, Chiang-Wen. Melanogenesis Inhibitor(s) from Phyla nodiflora Extract. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028594
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028594