HRT, Herbal Formula, Induces G2M Cell Cycle Arrest and Apoptosis via Suppressing Akt Signaling Pathway in Human Colon Cancer Cells
Joint Authors
Ma, Jin Yeul
Yim, Nam-Hui
Yang, Hye Jin
Lee, Ju Hye
Cho, Won-Kyung
Jung, Young Pil
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We have demonstrated the anticancer effect of HRT in HCT116, human colon carcinoma cells.
HRT inhibited cancer cell growth by causing cell cycle arrest at G2/M and inducing apoptosis as evidenced by DNA fragmentation assay.
We found that HRT induces the activation of caspase-3, -8, and -9, whereas it reduces the level of Bcl-2 protein and results in the cleavage of PARP.
Further, HRT decreased the level of phosphorylation of Akt and its downstream signals such as mTOR and GSK-3β.
These results indicate that HRT stimulates the apoptotic signaling pathway and represses the survival and proliferation of colon cancer cells via inhibiting Akt activity.
Hence, our results suggest that HRT has a potential to be developed as a therapeutic agent against colon cancer cells.
American Psychological Association (APA)
Yim, Nam-Hui& Cho, Won-Kyung& Lee, Ju Hye& Jung, Young Pil& Yang, Hye Jin& Ma, Jin Yeul. 2012. HRT, Herbal Formula, Induces G2M Cell Cycle Arrest and Apoptosis via Suppressing Akt Signaling Pathway in Human Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028595
Modern Language Association (MLA)
Yim, Nam-Hui…[et al.]. HRT, Herbal Formula, Induces G2M Cell Cycle Arrest and Apoptosis via Suppressing Akt Signaling Pathway in Human Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028595
American Medical Association (AMA)
Yim, Nam-Hui& Cho, Won-Kyung& Lee, Ju Hye& Jung, Young Pil& Yang, Hye Jin& Ma, Jin Yeul. HRT, Herbal Formula, Induces G2M Cell Cycle Arrest and Apoptosis via Suppressing Akt Signaling Pathway in Human Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028595
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028595