Inhibitory Activities of Cudrania tricuspidata Leaves on Pancreatic Lipase In Vitro and Lipolysis In Vivo
Joint Authors
Kim, Chan-Sik
Kim, Joo Hwan
Lee, Yun Mi
Kim, Young Sook
Lee, Youngseop
Song, Yoojin
Jo, Kyuhyung
Shin, So Dam
Sohn, Eun Jin
Kim, Jin Sook
Kim, Junghyun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To identify effective herb to treat obesity, we screened 115 herbal extracts for inhibition of porcine pancreatic lipase (triacylg-ycerol acylhydrolase, EC 3.1.1.3) activity in vitro.
Of the extracts tested, Cudrania tricuspidata leaves exhibited the most pronounced inhibitory effect on lipase activity with an IC50 value of 9.91 μg/mL.
Antilipid absorption effects of C.
tricuspidata leaves were examined in rats after oral administration of lipid emulsions containing 50 or 250 mg C.
tricuspidata/kg body weight.
Plasma triacylglycerol levels 2 h after the oral administration of emulsions containing C.
tricuspidata were significantly reduced compared to the untreated group (P<0.05).
These results suggest that C.
tricuspidata leaves may be useful for the treatment of obesity.
American Psychological Association (APA)
Kim, Young Sook& Lee, Youngseop& Kim, Junghyun& Sohn, Eun Jin& Kim, Chan-Sik& Lee, Yun Mi…[et al.]. 2012. Inhibitory Activities of Cudrania tricuspidata Leaves on Pancreatic Lipase In Vitro and Lipolysis In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028599
Modern Language Association (MLA)
Kim, Young Sook…[et al.]. Inhibitory Activities of Cudrania tricuspidata Leaves on Pancreatic Lipase In Vitro and Lipolysis In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028599
American Medical Association (AMA)
Kim, Young Sook& Lee, Youngseop& Kim, Junghyun& Sohn, Eun Jin& Kim, Chan-Sik& Lee, Yun Mi…[et al.]. Inhibitory Activities of Cudrania tricuspidata Leaves on Pancreatic Lipase In Vitro and Lipolysis In Vivo. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028599