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Anti-Inflammatory Effects of Bangpungtongsung-San, a Traditional Herbal Prescription
Joint Authors
Jo, Mi Jeong
Ahn, Yong-Tae
Lee, Jong Rok
Kwak, Tae Won
Kim, Jong Myoung
Kim, Sang Chan
An, Won G.
Lee, Chul Won
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Bangpungtongsung-san (BPTS), a traditional oriental herbal prescription, is widely used for expelling wind, draining heat, and providing general improvement to the immune system.
In this study, we investigated the effects of BPTS on induction of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), proinflammatory cytokines, nuclear factor-kappa B (NF-κB), and mitogen-activated protein kinases (MAPKs) in lipopolysaccharide- (LPS- ) stimulated Raw 264.7 cells, and on paw edema in rats.
At concentrations of 0.5, 0.75, and 1 mg/mL, treatment with BPTS inhibited levels of expression of LPS-induced NF-κB and MAPKs (ERK, JNK, and p38) as well as production of proinflammatory mediators, such as nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) by LPS.
These results suggest that BPTS may exert anti-inflammatory effects via reduction of proinflammatory mediators, including NO, PGE2, TNF-α, and IL-6 through suppression of the signaling pathways of NF-κB and MAPKs in LPS-induced macrophages.
In addition, using the carrageenan-induced paw edema assay, an antiedema effect of BPTS was observed in rats.
These findings may provide scientific evidence validating the use of BPTS in treatment of patients with heat syndrome in Korean oriental medicine.
American Psychological Association (APA)
Lee, Chul Won& Kim, Sang Chan& Kwak, Tae Won& Lee, Jong Rok& Jo, Mi Jeong& Ahn, Yong-Tae…[et al.]. 2012. Anti-Inflammatory Effects of Bangpungtongsung-San, a Traditional Herbal Prescription. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028603
Modern Language Association (MLA)
Lee, Chul Won…[et al.]. Anti-Inflammatory Effects of Bangpungtongsung-San, a Traditional Herbal Prescription. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1028603
American Medical Association (AMA)
Lee, Chul Won& Kim, Sang Chan& Kwak, Tae Won& Lee, Jong Rok& Jo, Mi Jeong& Ahn, Yong-Tae…[et al.]. Anti-Inflammatory Effects of Bangpungtongsung-San, a Traditional Herbal Prescription. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028603