Pistacia chinensis Methanolic Extract Attenuated MAPK and Akt Phosphorylations in ADP Stimulated Rat Platelets In Vitro
Joint Authors
Lee, Young-Chul
Jia, Qi
Yayeh, Taddesse
Kwak, Dong-Mi
Park, Ji Young
Cho, Jae Youl
Rhee, Man Hee
Ji, Hyun Dong
Hyun, Eujin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Pistacia chinensis (Chinese pistache) is a widely grown plant in southern China where the galls extract is a common practice in folk medicine.
However, extracts from this plant have never been attempted for their cardiovascular protective effects in experimental setting.
Here therefore we aimed to investigate the antiplatelet activity of Pistacia chinensis methanolic extract (PCME) in ADP stimulated rat platelets in vitro.
PCME(2.5–20 μg/mL) inhibited ADP-induced platelet aggregation.
While PCME diminished [Ca2+]i, ATP, and TXA2 release in ADP-activated platelets, it enhanced cAMP production in resting platelets.
Likewise, PCME inhibited fibrinogen binding to αIIbβ3 and downregulated JNK, ERK, and Akt phosphorylations.
Thus, PCME contains potential antiplatelet compounds that could be deployed for their therapeutic values in cardiovascular pathology.
American Psychological Association (APA)
Park, Ji Young& Ji, Hyun Dong& Jia, Qi& Lee, Young-Chul& Yayeh, Taddesse& Hyun, Eujin…[et al.]. 2012. Pistacia chinensis Methanolic Extract Attenuated MAPK and Akt Phosphorylations in ADP Stimulated Rat Platelets In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028607
Modern Language Association (MLA)
Park, Ji Young…[et al.]. Pistacia chinensis Methanolic Extract Attenuated MAPK and Akt Phosphorylations in ADP Stimulated Rat Platelets In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028607
American Medical Association (AMA)
Park, Ji Young& Ji, Hyun Dong& Jia, Qi& Lee, Young-Chul& Yayeh, Taddesse& Hyun, Eujin…[et al.]. Pistacia chinensis Methanolic Extract Attenuated MAPK and Akt Phosphorylations in ADP Stimulated Rat Platelets In Vitro. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028607