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Meta-Analysis of Randomized Controlled Trials on the Efficacy of Di’ao Xinxuekang Capsule and Isosorbide Dinitrate in Treating Angina Pectoris
Joint Authors
Chen, Cong
Ng, Choi-San
Leung, Siu-Wai
Jia, Yongliang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Randomized controlled trials (RCTs) on di’ao xinxuekang capsule (XXK) in treating angina pectoris were published only in Chinese and have not been systematically reviewed particularly for comparing XXK with isosorbide dinitrate (ISDN).
This study aims to provide a comprehensive PRISMA compliant and internationally accessible systematic review and meta-analysis to evaluate the efficacies of XXK and ISDN in treating angina pectoris.
Methods.
The RCTs published between 1989 and 2011 on XXK and ISDN in treating angina pectoris were selected according to specific criteria.
Meta-analysis was performed to evaluate the symptomatic (SYMPTOMS) and electrocardiographic (ECG) improvements after treatment.
Odds ratios (OR) were used to measure effect sizes.
Subgroup analysis, sensitivity analysis, and metaregression were conducted to evaluate the robustness of the results.
Results.
Seven RCTs with 550 participants were eligible.
Overall ORs for comparing XXK with ISDN were 4.11 (95% CI : 2.57, 6.55) in SYMPTOMS and 2.37 (95% CI : 1.46, 3.84) in ECG.
Subgroup analysis, sensitivity analysis, and metaregression found no significant dependence of overall ORs upon specific study characteristics.
Conclusion.
The meta-analysis of eligible but limited RCTs demonstrates that XXK seems to be more effective than ISDN in treating angina pectoris.
Further RCTs of high quality are warranted to be conducted for update of the results of this meta-analysis.
American Psychological Association (APA)
Jia, Yongliang& Chen, Cong& Ng, Choi-San& Leung, Siu-Wai. 2012. Meta-Analysis of Randomized Controlled Trials on the Efficacy of Di’ao Xinxuekang Capsule and Isosorbide Dinitrate in Treating Angina Pectoris. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028611
Modern Language Association (MLA)
Jia, Yongliang…[et al.]. Meta-Analysis of Randomized Controlled Trials on the Efficacy of Di’ao Xinxuekang Capsule and Isosorbide Dinitrate in Treating Angina Pectoris. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028611
American Medical Association (AMA)
Jia, Yongliang& Chen, Cong& Ng, Choi-San& Leung, Siu-Wai. Meta-Analysis of Randomized Controlled Trials on the Efficacy of Di’ao Xinxuekang Capsule and Isosorbide Dinitrate in Treating Angina Pectoris. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028611