The Cortical and Striatal Gene Expression Profile of 100 Hz Electroacupuncture Treatment in 6-Hydroxydopamine-Induced Parkinson's Disease Model
Joint Authors
Gong, Xiao-Li
Wang, Xiao-Min
Jia, Jun
Huo, Li-Rong
Liang, Xi-Bin
Liang, Jian-Tao
He, Yi
Jia, Yan-Jun
Yu, Fen
Li, Bo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Electroacupuncture (EA), especially high-frequency EA, has frequently been used as an alternative therapy for Parkinson disease (PD) and is reportedly effective for alleviating motor symptoms in patients and PD models.
However, the molecular mechanism underlying its effectiveness is not completely understood.
To implement a full-scale search for the targets of 100 Hz EA, we selected rat models treated with 6-hydroxydopamine into the unilateral MFB, which mimic end-stage PD.
High-throughput microarray analysis was then used to uncover the regulated targets in the cortex and striatum after 4-week EA treatment.
In the differentially regulated transcripts, the proportion of recovered expression profiles in the genes, the functional categories of targets in different profiles, and the affected pathways were analyzed.
Our results suggested that the recovery of homeostasis in the transcript network and many regulated functional clusters in the cortex and striatum after EA treatment may contribute to the behavioral improvement of PD rats.
American Psychological Association (APA)
Huo, Li-Rong& Liang, Xi-Bin& Li, Bo& Liang, Jian-Tao& He, Yi& Jia, Yan-Jun…[et al.]. 2012. The Cortical and Striatal Gene Expression Profile of 100 Hz Electroacupuncture Treatment in 6-Hydroxydopamine-Induced Parkinson's Disease Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1028612
Modern Language Association (MLA)
Huo, Li-Rong…[et al.]. The Cortical and Striatal Gene Expression Profile of 100 Hz Electroacupuncture Treatment in 6-Hydroxydopamine-Induced Parkinson's Disease Model. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-1028612
American Medical Association (AMA)
Huo, Li-Rong& Liang, Xi-Bin& Li, Bo& Liang, Jian-Tao& He, Yi& Jia, Yan-Jun…[et al.]. The Cortical and Striatal Gene Expression Profile of 100 Hz Electroacupuncture Treatment in 6-Hydroxydopamine-Induced Parkinson's Disease Model. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1028612
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028612