Comparison of a Chinese Herbal Medicine (CCH1)‎ and Lactulose as First-Line Treatment of Constipation in Long-Term Care: A Randomized, Double-Blind, Double-Dummy, and Placebo-Controlled Trial

Joint Authors

Li, Tsai-Chung
Huang, Chien-Hsun
Lee, Shih-Chang
Lue, Hung-Chi
Su, Yi-Chang
Wang, Hsiu-Po
Lin, Sunny Jui-Shan

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-03-18

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Medicine

Abstract EN

Many institutionalized patients and their healthcare providers are dissatisfied with current laxative therapy.

This study compared therapeutic efficacy, safety, and laxative cost of an herbal formula (CCH1) and lactulose for long stay patients with constipation.

In this double-blind, double-dummy, and placebo-controlled trial, we randomized 93 residents with chronic constipation from two long-term care facilities in Taiwan to receive either CCH1 with lactulose placebo or CCH1 placebo with lactulose for 8 weeks, then followed up for 4 weeks without study medication.

Both treatments were effective and well tolerated for patients, but CCH1 produced more spontaneous bowel movements, less rectal treatments, less amount of rescue laxative, and lower laxative cost than lactulose during treatment.

No significant differences were found in stool consistency, stool amount, global assessment, and safety concerns.

In conclusion, our results suggest that CCH1 may have better efficacy and could be used as an alternative option to lactulose in the treatment of constipation in long-term care.

American Psychological Association (APA)

Huang, Chien-Hsun& Lin, Sunny Jui-Shan& Li, Tsai-Chung& Lee, Shih-Chang& Wang, Hsiu-Po& Lue, Hung-Chi…[et al.]. 2012. Comparison of a Chinese Herbal Medicine (CCH1) and Lactulose as First-Line Treatment of Constipation in Long-Term Care: A Randomized, Double-Blind, Double-Dummy, and Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028619

Modern Language Association (MLA)

Huang, Chien-Hsun…[et al.]. Comparison of a Chinese Herbal Medicine (CCH1) and Lactulose as First-Line Treatment of Constipation in Long-Term Care: A Randomized, Double-Blind, Double-Dummy, and Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1028619

American Medical Association (AMA)

Huang, Chien-Hsun& Lin, Sunny Jui-Shan& Li, Tsai-Chung& Lee, Shih-Chang& Wang, Hsiu-Po& Lue, Hung-Chi…[et al.]. Comparison of a Chinese Herbal Medicine (CCH1) and Lactulose as First-Line Treatment of Constipation in Long-Term Care: A Randomized, Double-Blind, Double-Dummy, and Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028619

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1028619