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Phyllanthus urinaria Induces Apoptosis in Human Osteosarcoma 143B Cells via Activation of FasFasL- and Mitochondria-Mediated Pathways
Joint Authors
Lin, Tsu-Kung
Chuang, Jiin-Haur
Liou, Chia-Wei
Wu, Hsin-Yi
Kuo, Hsiao-Mei
Huang, Ya-Ling
Wang, Pei-Wen
Huang, Sheng-Teng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Phyllanthus urinaria (P.
urinaria), in this study, was used for the treatment of human osteosarcoma cells, which is one of the tough malignancies with few therapeutic modalities.
Herein, we demonstrated that P.
urinaria inhibited human osteosarcoma 143B cells growth through an apoptotic extrinsic pathway to activate Fas receptor/ligand expression.
Both intracellular and mitochondrial reactive oxygen species were increased to lead to alterations of mitochondrial membrane permeability and Bcl-2 family including upregulation of Bid, tBid, and Bax and downregulation of Bcl-2.
P.
urinaria triggered an intrinsic pathway and amplified the caspase cascade to induce apoptosis of 143B cells.
However, upregulation of both intracellular and mitochondrial reactive oxygen species and the sequential membrane potential change were less pronounced in the mitochondrial respiratory-defective 143Bρ0 cells compared with the 143B cells.
This study offers the evidence that mitochondria are essential for the anticancer mechanism induced by P.
urinaria through both extrinsic and intrinsic pathways.
American Psychological Association (APA)
Wu, Hsin-Yi& Lin, Tsu-Kung& Kuo, Hsiao-Mei& Huang, Ya-Ling& Liou, Chia-Wei& Wang, Pei-Wen…[et al.]. 2012. Phyllanthus urinaria Induces Apoptosis in Human Osteosarcoma 143B Cells via Activation of FasFasL- and Mitochondria-Mediated Pathways. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1028621
Modern Language Association (MLA)
Wu, Hsin-Yi…[et al.]. Phyllanthus urinaria Induces Apoptosis in Human Osteosarcoma 143B Cells via Activation of FasFasL- and Mitochondria-Mediated Pathways. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-1028621
American Medical Association (AMA)
Wu, Hsin-Yi& Lin, Tsu-Kung& Kuo, Hsiao-Mei& Huang, Ya-Ling& Liou, Chia-Wei& Wang, Pei-Wen…[et al.]. Phyllanthus urinaria Induces Apoptosis in Human Osteosarcoma 143B Cells via Activation of FasFasL- and Mitochondria-Mediated Pathways. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-1028621
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028621