Antiviral Activity of Isatis indigotica Extract and Its Derived Indirubin against Japanese Encephalitis Virus
Joint Authors
Chang, Yi-Chih
Lu, Kai-Zen
Tsou, Yi-Yun
Lin, Cheng-Wen
Chang, Shu-Jen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Isatis indigotica is widely used in Chinese Traditional Medicine for clinical treatment of virus infection, tumor, and inflammation, yet its antiviral activities remain unclear.
This study probed antiviral activity of I.
indigotica extract and its marker compounds against Japanese encephalitis virus (JEV).
I.
indigotica methanol extract, indigo, and indirubin proved less cytotoxic than other components, showing inhibitory effect (concentration-dependent) on JEV replication in vitro.
Time-of-addition experiments proved the extract, indigo, and indirubin with potent antiviral effect by pretreatment (before infection) or simultaneous treatment (during infection), but not posttreatment (after entry).
Antiviral action of these agents showed correlation with blocking virus attachment and exhibited potent virucidal activity.
In particular, indirubin had strong protective ability in a mouse model with lethal JEV challenge.
The study could yield anti-JEV agents.
American Psychological Association (APA)
Chang, Shu-Jen& Chang, Yi-Chih& Lu, Kai-Zen& Tsou, Yi-Yun& Lin, Cheng-Wen. 2012. Antiviral Activity of Isatis indigotica Extract and Its Derived Indirubin against Japanese Encephalitis Virus. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028622
Modern Language Association (MLA)
Chang, Shu-Jen…[et al.]. Antiviral Activity of Isatis indigotica Extract and Its Derived Indirubin against Japanese Encephalitis Virus. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028622
American Medical Association (AMA)
Chang, Shu-Jen& Chang, Yi-Chih& Lu, Kai-Zen& Tsou, Yi-Yun& Lin, Cheng-Wen. Antiviral Activity of Isatis indigotica Extract and Its Derived Indirubin against Japanese Encephalitis Virus. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028622